Idiopathic pulmonary fibrosis patients with severe physiologic impairment: characteristics and outcomes

Respiratory Research

Table 2 Clinical, physiological and functional characteristics of IPF patients with severe functional impairment (FVC ≤ 50% and/or DLco ≤ 30% predicted) based on their exercise need for supplemental oxygen (6MWT_RA versus \({\text{6MWT}}_{{{\text{O}}_{{2}} }}\))

	All patients	6MWT_RA	\({\text{6MWT}}_{{{\text{O}}_{{2}} }}\)	p-value
Patients, n (%)	242	95/231 (41%)	136/231 (59%)
Male, n (%)	196 (81%)	78 (82%)	113 (83%)	0.86
Age, years ± SD	72 ± 8	74 ± 8	71 ± 8	0.003
BMI, mean ± SD	28 ± 5	26 ± 4	29 ± 6	0.0004
Smokers, n, % (mean PY ± SD)	155, 68% (30 ± 23)	58, 61% (25 ± 20)	93, 68% (32 ± 25)	0.26
FVC% ± SD	53 ± 17	54 ± 16	52 ± 19	0.51
DLco% ± SD	28 ± 9	30 ± 9	26 ± 9	0.02
Mean O₂ flow rate, L/min		0	5
6MWD, meters ± SD	304 ± 121	337 ± 115	281 ± 118	0.0005
6MWT SpO₂ nadir, % ± SD	88 ± 5	91 ± 5	86 ± 5	< 0.0001
6MWT Borg max, mean ± SD	4 ± 2	3 ± 2	5 ± 2	0.0008

6MWT: 6-min walk test; 6MWT_RA: patients able to complete a 6MWT with SpO₂ > 86% on room air; \({\text{6MWT}}_{{{\text{O}}_{{2}} }}\): patients with need for supplemental oxygen during 6MWT; SD: standard deviation; BMI: body mass index; PY: pack-year; FVC%: forced vital capacity, % predicted; DLco%: single breath diffusing capacity for carbon monoxide; % predicted; 6MWD: 6-min walk test distance; SpO₂: blood oxygen saturation

ISSN: 1465-993X