Idiopathic pulmonary fibrosis patients with severe physiologic impairment: characteristics and outcomes

Respiratory Research

Table 1 Demographics, physiologic and functional data of all patients with severe functional impairment (FVC ≤ 50% and/or DLco ≤ 30% predicted)

	All patients	FVC ≤ 50% predicted only	DLco ≤ 30% predicted only	Both FVC ≤ 50% and DLco ≤ 30% predicted	p-value
Patients, n (%)	242	95 (39%)	94 (39%)	53 (22%)
Male, n (%)	196 (81%)	74 (78%)	79 (84%)	43 (81%)	0.08
Age, years ± SD	72 ± 8	72 ± 8^†	73 ± 8*^§	71 ± 7^†	0.01
BMI, mean ± SD	28 ± 5	27 ± 5	27 ± 5	31 ± 6	0.15
Smokers, n, % (mean PY ± SD)	155, 68% (30 ± 23)	54, 60%^† (22 ± 20)	69, 73%* (34 ± 25)	32, 60% (32 ± 21)	0.02
FVC% ± SD	53 ± 17	42 ± 7	70 ± 17	43 ± 5
DLco% ± SD	28 ± 9	39 ± 9	24 ± 4	24 ± 6
Available 6MWT, n (%)	231 (95%)	91 (99%)	92 (98%)	48 (91%)
6MWD, meters ± SD	304 ± 121	309 ± 123	319 ± 117^§	266 ± 116^†	0.04
\({\text{6MWT}}_{{{\text{O}}_{{2}} }}\), n (%)	140 (59%)	50 (54%)	53 (56%)	37 (70%)	0.08
\({\text{6MWT}}_{{{\text{O}}_{{2}} }}\) mean flow rate, L/min	5	4	5	5
6MWT SpO₂ nadir, % ± SD	88 ± 5	89 ± 5	88 ± 6	88 ± 5	0.51
6MWT max Borg, mean ± SD	4 ± 2	4 ± 2	4 ± 2	4 ± 2	0.29

BMI: body mass index; SD: standard deviation; PY: pack-year; FVC%: forced vital capacity, % predicted; DLco%: single breath diffusing capacity for carbon monoxide, % predicted; 6MWT: 6-min walk test; \({\text{6MWT}}_{{{\text{O}}_{{2}} }}\): patients with need for supplemental oxygen during 6MWT; 6MWD: 6-min walk test distance; SpO₂: blood oxygen saturation
^* p value < 0.05 when compared to patients with FVC ≤ 50% predicted only
^† p value < 0.05 when compared to patients with DLco ≤ 30% predicted only
^§ p value < 0.05 when compared to patients with both FVC ≤ 50% and DLco ≤ 30% predicted

ISSN: 1465-993X