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Fig. 4 | Respiratory Research

Fig. 4

From: Thymosin β10 promotes tumor-associated macrophages M2 conversion and proliferation via the PI3K/Akt pathway in lung adenocarcinoma

Fig. 4

TMSB10 promotes cell proliferation and M2 conversion of THP-1 and RAW264.7 via PI3K/Akt pathway. a THP-1 Supernatants were collected after 72 h treatment for analysis of IL-6, IL-10 and TNF-α and IL-12 secreted level (pg/ml) by ELISA. b RAW264.7 Supernatants were collected after 72 h treatment for analysis of IL-6, IL-10 and TNF-α and IL-12 secreted level (pg/ml) by ELISA. c The proliferation of THP-1 and RAW264.7 was detected by cell proliferation assay. d Immunoblotting result for TMSB10, Akt, p-Akt (Sec473), mTOR, p-mTOR (Sec2448), p70S6K, p-p70S6K (Thr389) and GAPDH proteins expression in THP-1 and RAW264.7 cells. Scr: scramble shRNA; TMSB10i: TMSB10 shRNA; Control: vector control; OVE: TMSB10 overexpression vector. The data represents mean ± SD in each group, n = 3; *P < 0.05, **P < 0.01

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Respiratory Research

ISSN: 1465-993X

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