RETRACTED ARTICLE: Targeting MALAT1 and miRNA-181a-5p for the intervention of acute lung injury/acute respiratory distress syndrome

Table 3 Arterial blood gases (mmHg) and W/D in rats

Parameters	Sham	LPS	LPS + siR-NC	LPS + siR-MALAT1	LPS + mimic NC	LPS + mimic miR-181a-5p	LPS + siR-MALAT1 + mimic miR 181a-5p
PaO₂
30 min before LPS	125.8 ± 6.6	131.9 ± 7.2	135.8 ± 8.7	129.3 ± 3.2	133.2 ± 8.4	129.5 ± 6.1	130.4 ± 6.9
6 h after LPS	140.2 ± 7.9	84.8 ± 6.3*	99.6 ± 4.5*	114.8 ± 9.2*	80.4 ± 2.8*	119.5 ± 7.7*	135.4 ± 5.2
12 h after LPS	138.3 ± 5.5	68.2 ± 4.1**	75.6 ± 2.9**	89.6 ± 5.7**	74.7 ± 7.1**	97.5 ± 9.3**	126.6 ± 4.7
PaCO₂
30 min before LPS	33.1 ± 3.4	32.1 ± 3.1	38.6 ± 2.1	30.4 ± 5.6	37.4 ± 6.6	33.5 ± 8.1	34.6 ± 5.5
6 h after LPS	39.5 ± 2.0	50.3 ± 3.5*	53.3 ± 1.6*	42.4 ± 3.5	46.8 ± 4.8*	36.2 ± 2.2	35.4 ± 2.9
12 h after LPS	40.0 ± 3.2	55.1 ± 1.8*	57.8 ± 2.9*	42.5 ± 4.3	58.5 ± 6.2*	41.3 ± 4.5	40.9 ± 7.7
W/D	4.17 ± 0.94	6.25 ± 2.83*	6.56 ± 1.74*	5.14 ± 1.85*	6.72 ± 1.42*	4.98 ± 3.19	4.26 ± 3.24

Data are presented as mean ± SD. P values were calculated using analysis of variance on repeated measures. LPS lipopolysaccharide, MALAT1 metastasis-associated lung adenocarcinoma transcript-1, W/D wet/dry ratio. *, **P < 0.05, 0.01 compared to sham group

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