Fig. 6

Interaction between MALAT1 and miR-181a-5p. a SiR-MALAT1 or siR-NC was transfected to HPMECs, which were then treated with LPS. SiR-MALAT1 decreased miR-181a-5p expression. b Mimic miR-181a-5p or mimic miR-NC was transfected to HPMECs, which were then treated with LPS. Mimic miR-181a-5p failed to alter MALAT1 expression. c pGL3-MALAT1-WT or pGL3-MALAT1-MUT plasmids were co-transfected with mimic miR-181a-5p or miR-NC. Luciferase assay revealed that mimic miR-181a-5p decreased the luciferase activity in pGL3-MALAT1-WT but not in pGL3-MALAT1-MUT. *, **p < 0.05, 0.01