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Table 4 Prediction of 6MWD Using Biomarker Value at Previous Visit in Patients with PAH

From: Treatment-related biomarkers in pulmonary hypertension patients on oral therapies

Biomarkera Estimate Standard error Standardized model coefficientsb p-value
ET-1 (N = 48) − 36.60 14.30 − 15.46 0.015
NT-proBNP (N = 49) − 7.00 4.62 − 8.63 0.14
RDW (N = 49) − 16.63 65.35 − 1.88 0.80
cGMP (N = 46) − 8.51 12.22 − 5.05 0.49
SNO-Hb (N = 41) − 5148.68 5365.76 − 3.69 0.35
cGMP/NTproBNP ratio (N = 44)
  Log(cGMP/NTproBNP + 1) ≤ 0.75c 59.91 33.47 25.21 0.083
  Log(cGMP/NTproBNP + 1) > 0.75c − 30.73 29.63 − 12.93 0.31
NO2 (N = 41) 3.31 9.53 3.64 0.73
ADMA (N = 46) − 0.0026 0.064 − 0.22 0.97
SDMA (N = 47) − 23.97 17.87 − 7.62 0.19
  1. aAll biomarkers were transformed as log(biomarker + 1) besides ADMA
  2. bStandarized model coefficients quantify change per 1 standard deviation increase in values of each biomarker
  3. cPer 1 unit increase on log scale