Table 2 Clinical characteristics and symptom burden of ILD patients with pain and no pain
|  | All patients N = 63 | Pain N = 39 | No-pain N = 24 | P value |
|---|---|---|---|---|
Age | 61 ± 10 | 62 ± 10 | 61 ± 11 | 0.437 |
 > 60 years | 39 (61.9%) | 23 (59.0%) | 16 (66.7%) | 0.601 |
Gender (Male) | 38 (60.3%) | 24 (63.2%) | 14 (58.3%) | 0.801 |
BMI (kg/m2) | 25.1 ± 3.5 | 25.4 ± 3.8 | 24.6 ± 2.8 | 0.093 |
Diagnosis | ||||
 IPF | 24 (38.1%) | 14 (35.9%) | 10 (41.7%) | 0.882 |
 CTD-ILD | 34 (54.0%) | 22 (56.4%) | 12 (50.0%) |  |
 Others | 5 (7.9%) | 3 (7.7%) | 2 (8.3%) |  |
 Smoker | 28 (44.4%) | 19 (48.7%) | 9 (37.5%) | 0.441 |
 Exposure history | 23 (36.5%) | 17 (43.6%) | 6 (25.0%) | 0.181 |
 Comorbidity | 34 (53.9%) | 25 (64.1%) | 9 (37.5%) | 0.040 |
FVC, % predicted | 74.5 ± 21.8 | 70.8 ± 15.8 | 80.3 ± 28.3 | 0.195 |
 < 80 | 32 (65.3%) | 22 (73.3%) | 10 (52.6%) | 0.138 |
 ≥ 80 | 17 (34.7%) | 8 (26.7%) | 9 (47.4%) |  |
DLCO, % predicted | 45.2 ± 14.2 | 44.1 ± 12.8 | 46.8 ± 16.5 | 0.525 |
 < 45 | 23 (48.9%) | 18 (62.1%) | 5 (27.8%) | 0.022 |
 ≥ 45 | 24 (51.1%) | 11 (37.9%) | 13 (72.2%) |  |
FEV1/FVC, % | 74.7 ± 26.1 | 74.4 ± 25.3 | 75.1 ± 28.0 | 0.572 |
 < 70 | 4 (8.1%) | 4 (10.3%) | 0 | 0.105 |
 ≥ 70 | 45 (91.9) | 35 (89.7%) | 10 (100.0%) |  |
6MWT | 333.2 ± 112.2 | 329.7 ± 100.7 | 338.5 ± 129.0 | 0.801 |
 6MWD < 250 m | 9 (14.2%) | 5 (55.6%) | 4 (44.4%) | 0.893 |
 6MWD ≥ 250 m | 31 (49.2%) | 18 (58.1%) | 13 (41.9%) | |
6MWT SpO2, before (%) | 94.5 ± 3.8 | 94.7 ± 3.4 | 94.1 ± 4.4 | 0.654 |
6MWT SpO2, later (%) | 88.7 ± 8.4 | 89.9 ± 8.5 | 88.2 ± 8.5 | 0.809 |
mMRC score | ||||
 0–1 (n%) | 24 (38.1%) | 7 (17.9%) | 11 (45.8%) | 0.023 |
 2–4 (n%) | 39 (61.9%) | 32 (82.1%) | 13 (54.2%) | |
HAD anxious | ||||
 No case (n%) | 43 (68.2%) | 23 (59.0%) | 21 (87.5%) | 0.017 |
 Borderline and case (n%) | 19 (30.2%) | 16 (41.0%) | 3 (12.5%) | |
HAD depression | ||||
 No case (%) | 43 (68.2%) | 23 (59.0%) | 20 (83.3%) | 0.044 |
 Borderline and case (%) | 20 (31.7%) | 16 (41.0%) | 4 (16.7%) | |
SF-36 | ||||
 Social functioning | 7.7 ± 2.5 | 7.3 ± 2.4 | 8.1 ± 2.4 | 0.265 |
 Mental health | 20.1 ± 5.8 | 18.9 ± 5.3 | 33.0 ± 6.1 | 0.029 |
 Bodily pain | 10.4 ± 4.3 | 9.5 ± 4.1 | 11.7 ± 4.2 | 0.049 |
 Vitality | 14.4 ± 5.6 | 13.2 ± 5.6 | 16.2 ± 5.5 | 0.043 |
 Role emotional | 3.8 ± 1.3 | 3.4 ± 1.1 | 4.3 ± 1.3 | 0.006 |
 Physical functioning | 17.1 ± 8.4 | 16.2 ± 8.1 | 18.6 ± 9.1 | 0.294 |
 General health | 16.3 ± 3.6 | 16.1 ± 3.5 | 16.8 ± 3.8 | 0.474 |
 Role physical | 6.2 ± 4.0 | 5.7 ± 3.7 | 7.0 ± 4.4 | 0.218 |
 Health Transition | 2.5 ± 1.1 | 2.4 ± 1.1 | 2.5 ± 1.2 | 0.661 |
 SF Total score | 98.7 ± 22.9 | 93.0 ± 20.0 | 107.5 ± 24.6 | 0.014 |