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Table 2 Study outcomes

From: Automated computed tomography quantification of fibrosis predicts prognosis in combined pulmonary fibrosis and emphysema in a real-world setting: a single-centre, retrospective study

 

Overall,

N = 228

Fibrosisa < 5%,

N = 89

Fibrosis 5–10%,

N = 54

Fibrosis ≥ 10%,

N = 85

p value b

Composite progression (%)

127 (55.7)

16 (18.0)

42 (77.8)

69 (81.2)

 < 0.001

All deaths (%)

75 (32.9%)

4 (4.5)

22 (40.7)

49 (57.6)

 < 0.001

Respiratory-related deaths (%)

47 (20.6)

2 (2.2)

14 (25.9)

31 (36.5)

 < 0.001

Acute exacerbation (%)

35 (15.4)

0 (0.0)

10 (18.5)

25 (29.4)

 < 0.001

Progression in pulmonary function tests (%)

67 (29.4%)

12 (13.5)

31 (57.4)

24 (28.2)

 < 0.001

Change in median body mass index/year (IQR)

− 0.02 (− 0.34, 0.26)

0.00 (− 0.15, 0.17)

− 0.10 (− 0.28, 0.17)

− 0.04 (− 0.30, 0.12)

0.103

Smoking cessation during the follow-up period (%)

40 (17.5)

18 (50.0)

9 (60.0)

13 (59.1)

0.718

Changes in forced vital capacityc

     

Median absolute change/year, L (IQR)

− 0.06 (− 0.15, 0.02)

− 0.02 (− 0.07, 0.04)

− 0.12 (− 0.23, − 0.08)

− 0.07 (− 0.16, 0.06)

 < 0.001

Median relative change/year, % (IQR)

− 1.67 (− 4.57, 0.66)

− 2.88 (− 8.41, 3.08)

− 13.66 (− 22.01, − 5.56)

− 4.30 (− 15.27, 7.87)

 < 0.001

Changes in DLco

     

Median absolute change/year, ml/min/mmHg (IQR)

− 0.25 (− 0.49, 0.11)

− 0.05 (− 0.24, 0.64)

− 0.93 (− 2.46, − 0.08)

− 0.31 (− 0.46, 0.00)

0.057

Median relative change/year, % (IQR)

3.03 (1.72, 5.60)

1.46 (− 0.91, 3.90)

− 3.90 (− 21.74, − 0.09)

− 1.36 (− 2.02, 1.36)

0.05

Changes in composite physiologic indexd

     

median absolute change/year (IQR)

0.93 (− 5.54, 10.11)

0.55 (− 5.08, 5.43)

1.33 (− 5.73, 12.48)

0.28 (− 4.98, 7.58)

0.86

Changes in computed tomography findings, median, %/year (IQR)

     

Total lung volume

− 6.97 (− 16.91, − 0.15)

− 3.69 (− 10.11, 1.32)

− 12.87 (− 24.13, − 2.95)

− 11.46 (− 21.46, − 2.64)

 < 0.001

Extent of normal lung

− 1.69 (− 4.08, 0.53)

− 1.21 (− 2.57, − 0.47)

− 2.21 (− 4.09, − 1.35)

− 2.11 (− 5.48, − 0.50)

0.083

Extent of emphysema

0.68 (− 0.01, 1.92)

0.49 (− 0.01, 1.77)

0.70 (0.01, 1.50)

0.96 (− 0.02, 2.43)

0.505

Extent of fibrosis

1.57 (0.10, 3.85)

0.21 (− 0.03, 0.91)

1.64 (0.33, 4.05)

0.89 (0.11, 4.14)

0.001

  1. IQR interquartile range, FVC forced vital capacity, DLco diffusing capacity for carbon monoxide
  2. aExtent of fibrosis was defined the extent (%) of combined reticular shadow, grand glass opacity, and honeycombing resulted in CALIPER. Twenty-nine CT series were unavailable for CALIPER analysis because of CT condition
  3. bP values are reported for the difference between groups between fibrosis proportions, using a × 2 test, Fisher exact test, t test, or Wilcoxon rank-sum test as appropriate
  4. cChange in FVC was calculated as the relative change (FVC baseline − FVC timepoint 2/FVC baseline, using either FVC in litres or % predicted FVC) and absolute change (FVC baseline − FVC timepoint 2, using % predicted FVC)
  5. dComposite physiologic index = 91.0 − [0.53 × percent predicted FVC] − [0.65 × percent predicted DLco] + [0.34 × percent predicted FEV1]
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Respiratory Research

ISSN: 1465-993X

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