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Table 1 Subject characteristics

From: Mitochondrial dysfunction in airways and quadriceps muscle of patients with chronic obstructive pulmonary disease

  Never-smokers
n = 5
Ex-smokers
n = 8
GOLD Grade 2
n = 6
GOLD Grade 3/4
n = 6
Age (years) 61 ± 6 63 ± 5 64 ± 3 64 ± 7
Female: Male 1:4 3:5 4:2 1:5
Cigarette smoking
(pack years)
0 ± 0 36 ± 16 34 ± 12 40 ± 6
Body mass index (kg/m2) 24 ± 5 25 ± 4 29 ± 7 23 ± 3 #
CAT score 2 (0–6) 8 (2–15) 16 (4–23) 24 (20–26)**#
FEV1 (L) 2.9 ± 0.4 2.9 ± 0.7 1.9 ± 0.3 0.8 ± 0.3**###
FEV1 (% pred) 100 ± 9 103 ± 11 71 ± 5* 30 ± 11**##
FVC (L) 4.3 ± 0.8 4.4 ± 1.0 3.0 ± 0.7 3.1 ± 1.3
FEV1/FVC (%) 69 ± 6 67 ± 7 63 ± 8 28 ± 9**##
TLCOc (% pred) 90 ± 14 80 ± 10 67 ± 8* 38 ± 13**##
6-min walk (m) 657 ± 18 631 ± 55 493 ± 66** 364 ± 65**##
VO2 Peak (ml/kg/min) 28 ± 3 25 ± 3 17 ± 3** 12 ± 4**#
QMVC (Kg) 34 ± 6 41 ± 11 31 ± 8 32 ± 6
QMVC/BMI 1.5 ± 0.1 1.6 ± 0.4 1.1 ± 0.3* 1.4 ± 0.2
SPPB 12 12 (11–12) 11 (10–12) 11 (9–12)
  1. BMI Body Mass Index; CAT score: COPD Assessment Test score; FEV1 Forced Expiratory Volume in one sec; 6 MW: 6-Minute Walk; QMVC Quadriceps Maximal Voluntary Contraction; SPPB Short Physical Performance Battery; TLCOc Single-breath transfer factor of the lung for carbon monoxide; VO2 Oxygen consumption. Data shown as mean ± SD or median (range). * p < 0.05 compared to never smoker or ex-smoker, **p < 0.01 compared to never smoker or ex-smoker, #p < 0.05 compared to GOLD Grade 2, ## p < 0.01 compared to GOLD Grade 2, ### p < 0.01 compared to GOLD Grade 2