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Table 3 Proposed respiratory support based on the severity of acute respiratory failure

From: COVID-19 multidisciplinary high dependency unit: the Milan model

Acute Respiratory failure

Alternative

▪ P/F ratio > 300 and respiratory rate (RR) < 30

▪ Low-flow nasal cannula oxygen or Venturi Mask or Reservoir Mask set with the aim of target SpO2 92–96%

▪ HFNC 40 L/min and FiO2 set with the aim of target SpO2 92–96%

▪ P/F ratio 100–300 and RR < 30

▪ Helmet CPAP with PEEP 5 or 7.5 cmH2O and FiO2 set with the aim of target SpO2 92–96%

▪ P/F ratio < 100 and RR < 30

▪ Helmet CPAP with PEEP 5 or 7.5 cmH2O and FiO2 set with the aim of target SpO2 92–96%

▪ P/F ratio < 100 and RR ≥ 30 and/or respiratory distress

▪ NIV (Also to consider in case of: CPAP failure, hyper-capnia). NIV starting parameters: PEEP 12–16 cmH20 PS set with the aim of Vt 4–6 ml/kg and FiO2 set with the aim of target SpO2 90–95%

  1. Abbreviations: P/F ratio arterial pO2 divided by the fraction (percent) of inspired oxygen, HFNC High-flow nasal cannula, CPAP Continuous positive airway pressure, FiO2 fraction (percent) of inspired oxygen, NIV Non-invasive ventilation, PEEP Positive end-expiratory pressure