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Table 2 Rate ratio of annual exacerbation rates according to exacerbation history by baseline eosinophil count (cells/μL)

From: Blood eosinophils as a biomarker of future COPD exacerbation risk: pooled data from 11 clinical trials

  

≤ 150 cells/μL

> 150–≤ 300 cells/μL

> 300 cells/μL

All

All patients n = 22,125

Rate: 0.62

Rate: 0.65

RR: 1.05

(95% CI 1.00, 1.11)

Rate: 0.67

RR: 1.09

(95% CI 1.03, 1.15)

Exacerbation history

0 exacerbations n = 6792

Rate: 0.38

Rate: 0.39

RR: 1.01

(95% CI 0.90, 1.12)

Rate: 0.44

RR: 1.14

(95% CI 1.00, 1.30)

1 exacerbation n = 9759

Rate: 0.62

Rate: 0.66

RR: 1.07

(95% CI 0.99, 1.15)

Rate: 0.67

RR: 1.10

(95% CI 1.01, 1.19)

≤ 1 exacerbation n = 16,551

Rate: 0.51

Rate: 0.53

RR: 1.04

(95% CI 0.98, 1.11)

Rate: 0.57

RR: 1.10

(95% CI 1.03, 1.19)

≥ 2 exacerbations n = 5574

Rate: 1.02

Rate: 1.10

RR: 1.08

(95% CI 0.99, 1.16)

Rate: 1.07

RR: 1.04

(95% CI 0.95, 1.15)

  1. RR versus ≤ 150 cells/μL eosinophil subgroup.
  2. CI Confidence interval; RR Rate ratio.