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Table 2 lipid metabolite levels in serum of ABPA, asthmatic patients and healthy control groups

From: Analysis of serum polyunsaturated fatty acid metabolites in allergic bronchopulmonary aspergillosis

 

ABPA (N = 12)

Asthma (N = 23)

HC (N = 12)

AA

3018.84

[2596.09–3296.18]

3619.61

[2926.52–4309.04]

1232.41

[889.29–1872.78] *□□□

15(S)-HPETE

0.84

[0.54–1.26]

2.62

[1.45–4.14] **

0.80

[0.46–1.06] □□

12(S)-HPETE

0.89

[0.26–3.62]

1.33

[0.89–2.34]

0.47

[0.25–1.07] □

5(S)-HPETE

0.43

[0.35–0.55]

0.94

[0.56–1.37] **

0.37

[0.23–0.44] □□

15(S)-HETE

11.56

[8.06–14.20]

6.50

[3.52–14.27]

1.16

[0.38–2.65] ***□□

12(S)-HETE

367.36

[290.68–546.39]

214.22

[54.38–552.75]

11.10

[17.54–128.41] ***□□

11(S)-HETE

3.38

[2.79–4.54]

3.28

[1.38–6.24]

0.80

[0.44–1.57] **□□

8(S)-HETE

1.83

[1.25–2.68]

1.13

[0.51–2.32]

0.48

[0.22–0.64] **□

5(S)-HETE

2.98

[2.06–8.89]

3.65

[2.09–14.29]

0.84

[0.55–1.19] ** □□□

LTB4

0.22

[0.16–0.33]

0.14

[0.03–0.28]

0.06

[0.01–0.19]*

15(S)-HEPE

0.27

[0.19–0.71]

0.19

[0.08–0.41]

0.07

[0.03–0.11]

12(S)-HEPE

5.48

[3.27–8.40]

2.85

[1.01–6.05]

0.18

[0.18–13.63]*** □□

5(S)-HEPE

0.36

[0.19–1.02]

0.68

[0.44–1.67]

0.16

[0.05–0.48]

9(S)-HPODE

5.31

[4.27–9.47]

12.58

[7.35–25.32]*

7.16

[3.83–9.37]

13(S)-HPODE

5.38

[4.26–9.51]

12.7

[6.71–25.99]*

7.61

[3.75–9.66]

PGB2

0.17

[0.08–0.24]

0.04

[0.01–0.13]

0.18

[0.09–0.37]***□

12HHTrE

86.00

[63.40–91.69]

47.20

[27.55–86.35]

3.70

[2.15–17.03]***□

11 (12)-HETE

0.67

[0.44–1.34]

0.64

[0.41–1.24]

0.23

[0.17–0.35]** □□

  1. Values are presented as medians [25–75 interquartile range]
  2. * P-values compared with ABPA patients: *P < 0.05, **P < 0.01, ***P < 0.001
  3. □P-values compared with asthma patients: □P < 0.05, □□P < 0.01, □□□P < 0.001
  4. ABPA Allergic bronchopulmonary aspergillosis, HC Healthy controls, AA Arachidonic acid, HPETE Hydroperoxyeicosatetraenoic Acid, HETE Hydroxyeicosatetraenoic acid, LTB4 Leukotriene B4, HEPE Hydroxyeicosapentaenoic acid, HPODE Hydroperoxyoctadecadienoic acid, PGB2 Prostaglandin B2, HHTrE Hydroxyheptadecatrienoic acid
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Respiratory Research

ISSN: 1465-993X

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