Skip to main content

Table 3 Multivariable linear regression models of the association between gastroesophageal reflux disease (GERD) and slopes of lung function. ß coefficients reflect the mean differences in the row outcome of interest between those with GERD compared to those without GERD

From: Impact of gastroesophageal reflux on longitudinal lung function and quantitative computed tomography in the COPDGene cohort

 

Any GERD

n = 2101

Persistent GERD

n = 1080

Incident GERD

n = 604

Resolved GERD

n = 417

Adjusted ß Estimate

(95% CI)

Adjusted ß Estimate

(95% CI)

Adjusted ß Estimate

(95% CI)

Adjusted ß Estimate

(95% CI)

Spirometry

 FEV1 (mL/yr)

−2.53 (− 5.43, 0.37)

− 2.07 (− 5.75, 1.61)

−5.47 (− 9.87, − 1.07)

−0.24 (− 5.87, 5.39)

 FVC (mL/yr)

−3.05 (− 7.29, 1.19)

− 1.69 (− 7.01, 3.63)

−6.29 (− 13.0, 0.42)

−1.62 (− 9.38, 6.15)

  1. Adjustment was made for the following variables: age, sex, race, smoked between phase I and II, BMI, clinical center, FEV1% predicted at Phase I, and acute exacerbation ≥1 between phase I and II
  2. Definitions: Any GERD, Phase I = ‘yes’ or Phase II = ‘yes’; Persistent GERD, Phase I = ‘yes’ and Phase II = ‘yes’; Incident GERD, Phase I = ‘no’ and Phase II = ‘yes’; and Resolved GERD, Phase I = ‘yes’ and Phase II = ‘no’
  3. Abbreviations: GERD gastroesophageal reflux disease, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity and CI confidence interval
Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us