Characteristics | Non-smokersa (N = 17) | Smokersa (N = 30) | COPD GOLD stages I-II (N = 31) | COPD GOLD stages III-IV (N = 17) | P valuec |
---|---|---|---|---|---|
Number of males (%) | 12 (70) | 20 (67) | 22 (70) | 12 (70) | NS |
Age (years) | 45 (20–77) | 62 (25–78) | 67 (50–81) | 60 (49–73) | P ≤ 0.02d |
Pack-yrs. of smoking | 0 | 41 (15–80) | 53 (20–100) | 58 (10–114) | P ≤ 0.03e |
Number of current smokers (%) | 0 (0) | 13 (43) | 18 (58) | 3 (18) | P ≤ 0.02f |
FEV1(% of predicted)b | 93 (79–104) | 94 (65–115) | 75 (51–118) | 29 (10–48) | P ≤ 0.008g |
FEV1/FVC (% of predicted)b | 80 (73–84) | 78 (71–89) | 61 (47–68) | 43 (25–60) | P < 0.001h |
ADAM15mRNA Levels in Lungs | 1 ± 0.6 | 0.84 ± 0.6 | 0.82 ± 0.5 | 2 ± 0.8 | P = 0.001i |