Fig. 4

SARS-CoV-2 infection induces Ace2 gene and its interacting factors in human alveolar but not bronchial epithelial cells. Human bronchial epithelial cells (HBEC) and alveolar epithelial (A549) cells were infected with SARS-CoV-2 for 24 h, and control cells received medium only. The mRNA expression of ACE2 (a), TMPRSS2 (b), ADAM17 (c), TIMP3 (d), AGF (e), TGFB1 (f), CTGF (g), VEGFA (h) and FN1 (i) in HBECs and alveolar epithelia cells. n = 2–3, *P < 0.05, **P < 0.01 compared to control cells