Fig. 2

pIC-exacerbated lung inflammation depends on IL-17RE. OVA-sensitized and challenged WT and Il-17re^−/− mice were intranasally treated with 100 μg pIC or PBS as control. a Schema of the experimental protocol to study pIC-exacerbated OVA-induced allergic lung inflammation. Mice were treated with pIC or PBS as control 2 h after the final OVA challenge. BAL fluid concentrations of KC (b) and lung tissue concentrations of KC (c), MIP-2 (d), G-CSF (e), CCL5 (f), IL-5 (g), IL-13 (h), TNF-α (i), and IL-6 (j) were measured 22 h after treatment with pIC or PBS. Data were compared by Two-way ANOVA with Tukey’s post-test and are shown as the mean ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001