Table 2 Summary data of analysis datasets with respect to recurrent exacerbations and early discontinuations
Dataset A | Dataset B | Dataset C | Dataset D | Dataset E | |
|---|---|---|---|---|---|
Number of patients available for analysis | 1746 | 1072 | 1613 | 1218 | 2049 |
Number of mod/sev exacerbations | 1186 | 949 | 655 | 1350 | 2179 |
Number of patients with R number of mod/sev exacerbations | |||||
R = 0 | 1086 | 537 | 1170 | 604 | 920 |
R = 1 | 376 | 286 | 301 | 265 | 554 |
R ≥ 2 | 284 | 249 | 142 | 349 | 575 |
Percentage of patients with ≥1 mod/sev exacerbation | 37.8% | 49.9% | 27.5% | 50.4% | 55.1% |
Max. number of mod/sev exacerbations | 12 | 10 | 6 | 11 | 11 |
Mean number of mod/sev exacerbations per patient years at risk | 0.816 | 1.051 | 0.917 | 1.284 | 1.293 |
Number of early treatment discontinuations | 392 | 221 | 235 | 180 | 421 |
Percentage of early treatment discontinuations | 22.5% | 20.6% | 14.6% | 14.8% | 20.5% |
Percentage of early treatment discontinuations in original data | 31% | 30% | 19% | 24% | 25% |