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Table 5 Adjusted odd ratios (ORs) and 95% confidence interval (CIs) of insulin resistance associated with total sleep duration in stratified analysis by OSA severity

From: Interaction between obstructive sleep apnea and short sleep duration on insulin resistance: a large-scale study

predictors

n

OR(95% CI)

Model 1

Model 2

Model 3

Model 4

Model 5

Primary snoring

940

Reference

Reference

Reference

Reference

Reference

Mild OSA

  > 8 h

57

0.942 (0.501–1.774)

0.999 (0.523–1.909)

0.920 (0.438–1.930)

0.934 (0.436–1.999)

0.896 (0.402–1.997)

 7-8 h

262

1.208 (0.882–1.655)

1.142 (0.828–1.575)

1.055 (0.659–1.688)

1.052 (0.652–1.698)

1.012 (0.613–1.668)

 6-7 h

284

0.953 (0.696–1.304)

0.917 (0.665–1.264)

0.845 (0.530–1.352)

0.821 (0.511–1.320)

0.856 (0.521–1.405)

 5–6

163

1.163 (0.794–1.705)

1.155 (0.783–1.705)

1.069 (0.639–1.788)

1.054 (0.621–1.788)

1.017 (0.581–1.779)

  ≤ 5 h

112

1.903 (1.213–2.986) *

1.735 (1.104–2.784) *

1.621 (0.913–2.875)

1.582 (0.876–2.856)

1.693 (0.921–3.112)

Moderate OSA

  > 8 h

80

1.150 (0.690–1.920)

1.102 (0.656–1.850)

1.114 (0.494–2.515)

1.164 (0.509–2.664)

1.156 (0.490–2.729)

 7-8 h

268

1.325 (0.966–1.816)

1.253 (0.910–1.726)

1.268 (0.620–2.592)

1.270 (0.612–2.635)

1.170 (0.548–2.497)

 6-7 h

273

1.300 (0.953–1.773)

1.268 (0.922–1.743)

1.282 (0.626–2.627)

1.343 (0.649–2.777)

1.399 (0.658–2.974)

 5–6

164

1.735 (1.183–2.544) *

1.736 (1.176–2.563)

1.755 (0.831–3.707)

1.889 (0.883–4.042)

1.961 (0.893–4.308)

  ≤ 5 h

106

1.808 (1.154–2.832) *

1.781 (1.128–2.813) *

1.801 (0.817–3.970)

1.824 (0.816–4.076)

2.039 (0.889–4.678)

Severe OSA

  > 8 h

329

1.535 (1.131–2.084) *

1.249 (0.912–1.711)

0.510 (0.330–0.788)

0.486 (0.312–0.757)

0.503 (0.318–0.795)

 7-8 h

963

1.944 (1.551–2.436) *

1.668 (1.318–2.110) *

0.699 (0.481–1.015)

0.698 (0.478–1.020)

0.718 (0.486–1.063)

 6-7 h

854

1.847 (1.464–2.331) *

1.654 (1.298–2.109) *

0.689 (0.471–1.007)

0.683 (0.465–1.004)

0.709 (0.476–1.057)

 5–6

353

2.200 (1.637–2.957) *

1.978 (1.459–2.683) *

0.833 (0.548–1.267)

0.787 (0.514–1.205)

0.818 (0.528–1.269)

  ≤ 5 h

239

2.141 (1.531–2.994)*

1.970 (1.389–2.793) *

0.845 (0.539–1.326)

0.823 (0.521–1.300)

0.813 (0.507–1.302)

  1. Model 1 was adjusted for age, sex and BMI; model 2 was adjusted for variables included in model 1 and smoking, alcohol use, hypertension, hyperlipidemia, time in bed, S3, ESS; model 3 was adjusted for variables included in model 2 and TST (or AHI); model 4 was adjusted for variables included in model 3 and waist hip ratio; model 5 was adjusted for variables in model 4 and additional diabetes mellitus, apolipoprotein A-1, apolipoprotein-B, apolipoprotein-E and lipoprotein-α
  2. Acronyms: OSA Obstructive sleep apnea, OR Odds ratio, CI Confidence interval, BMI Body mass index, ESS Epworth Sleepiness Scale, AHI Apnea-hypopnea index
  3. * p indicates a significant difference