Role of serum periostin in severe obstructive sleep apnea with albuminuria: an observational study

Respiratory Research

Table 1 Patient characteristics

Index
Clinical background
Age, years	56 ± 11
Sex, male/female, n	74/22
BMI, kg/m²	27.6 ± 4.2
Abdominal circumference, cm	94.8 ± 20.7
Smoking, current/others, n	21/75
Sleep parameters
AHI, events/h	36.5 ± 20.7
CT₉₀, %	13.1 ± 18
Lowest oxygen saturation, %	78.9 ± 8.3
3% ODI, events/h	35.3 ± 20.5
Arousal index, events/h	34.4 ± 17.8
OSA, mild/moderate/severe^a, n	12/31/53
Comorbidities
Diabetes mellitus, +/−, n	26/70
Insulin use, +/−, n	5/91
Hypertension, +/−, n	58/38
Hypertension (self-reported), +/−, n	65/31
Dyslipidemia, +/−, n	62/34
Albuminuria^b, macro/micro/−, n	2/12/82
Chronic obstructive pulmonary disease, +/−, n	2/94
Asthma, +/−, n	4/92
Allergic rhinitis, +/−, n	16/80
Blood/Urine tests
Total cholesterol, mg/dL	196 ± 34
High-density lipoprotein, mg/dL	53 ± 15
Low-density lipoprotein, mg/dL	117 ± 30
Triglycerides, mg/dL	172 ± 121
Free fatty acids, mg/dL	490 ± 160
Blood glucose, mg/dL	101 ± 24
Hemoglobin A1c, %	6.2 ± 0.9
Insulin, μU/mL	10.7 ± 10.2
Serum periostin, ng/mL	67.3 ± 22.8
Urinary albumin–creatinine ratio^c, mg/g	25.4 ± 107.1

Baseline data are presented as mean ± SD or number
^aSeverity of OSA was defined on the basis of the AHI, as follows: mild, ≥5 to < 15;
moderate, ≥15 to < 30; or severe, AHI ≥30
^bDefined as positive if the urinary albumin–creatinine ratio was ≥20 mg/g in men or ≥ 30 mg/g in women. ^cDefined as urine albumin/creatinine
BMI body mass index, AHI apnea–hypopnea index, CT₉₀ cumulative percentage of sleep time with percutaneous oxygen saturation < 90%, ODI oxygen desaturation index

ISSN: 1465-993X