Table 4 On-treatment MACE (ITT population)
|  | FF/UMEC/VI (N = 4151) | FF/VI (N = 4134) | UMEC/VI (N = 2070) | |||
|---|---|---|---|---|---|---|
Total duration at risk (patient-years) | 3714.9 | 3457.9 | 1698.3 | |||
| Â | n (%) | Rate [#] | n (%) | Rate [#] | n (%) | Rate [#] |
Narrow definition | ||||||
Any MACE | 80 (2) | 22.3 [83] | 60 (1) | 18.8 [65] | 37 (2) | 22.4 [38] |
 Adjudicated CV death | 20 (< 1) | 5.4 [20] | 27 (< 1) | 7.8 [27] | 16 (< 1) | 9.4 [16] |
 Non-fatal CNS hemorrhages and cerebrovascular conditions (SMQ) | 38 (< 1) | 10.8 [40] | 21 (< 1) | 7.2 [25] | 10 (< 1) | 5.9 [10] |
 Non-fatal MI (PT) | 9 (< 1) | 2.4 [9] | 6 (< 1) | 1.7 [6] | 5 (< 1) | 2.9 [5] |
 Non-fatal acute MI (PT) | 13 (< 1) | 3.8 [14] | 7 (< 1) | 2.0 [7] | 7 (< 1) | 4.1 [7] |
Broad definition | ||||||
Any MACE | 133 (3) | 44.7 [166] | 100 (2) | 35.3 [122] | 66 (3) | 44.8 [76] |
 Adjudicated CV death | 20 (< 1) | 5.4 [20] | 27 (< 1) | 7.8 [27] | 16 (< 1) | 9.4 [16] |
 Non-fatal CNS hemorrhages and cerebrovascular conditions (SMQ) | 38 (< 1) | 10.8 [40] | 21 (< 1) | 7.2 [25] | 10 (< 1) | 5.9 [10] |
 Non-fatal MI (SMQ) | 49 (1) | 14.0 [52] | 29 (< 1) | 9.3 [32] | 24 (1) | 14.7 [25] |
 Non-fatal other ischemic heart disease (SMQ) | 41 (< 1) | 14.5 [54] | 32 (< 1) | 11.0 [38] | 25 (1) | 14.7 [25] |