Validation of a method to assess emphysema severity by spirometry in the COPDGene study

Respiratory Research

Table 1 Anthropometric, pulmonary function and CT metrics data of the 5930 subjects of the COPDGene population included in the study

Men/Women Non-Hispanic Whites/African Americans	3128/2802 4389/1541
PRISm/GOLD0/GOLD1–4	641/2646/2643
Age (yr)	60.1 (8.9)
BMI (kg/m²)	28.8 (6.2)
Smoking history (pack/years)	44.2 (24.6)
FEV₁ (%pred)	77.4 (25.0)
FVC (%pred)	87.9 (17.8)
FEV₁/FVC	0.66 (0.16)
PEF (L/s)	6.4 (2.4)
FEF25% (L/s)	4.8 (2.6)
FEF50% (L/s)	2.5 (1.7)
FEF75% (L/s)	0.6 (0.5)
FVC (L)	3.4 (1.0)
AWTPi10^a	3.7 (0.1)
%LAA_-950insp^a	6.5 (9.7)
%LAA_-856exp^a	21.6 (19.5)
%pLDA^b	4.5 (9.3)
%fLDA^b	19.5 (14.2)

Data are expressed as mean (SD) or absolute numbers. AWTPi10 = Average wall thickness of bronchi with an internal perimeter of 10 mm, BMI = Body mass index, FEF = Forced expiratory flow, FEV₁% = forced expiratory volume in 1 sec, %fLDA = percentage of functional low density area, FVC = Forced vital capacity, GOLD = Global initiative for chronic Obstructive Lung Disease; %LAA_-950insp = percentage of lung attenuation area with values <− 950 Hounsfield Units at inspiratory CT scan, %LAA_-856exp = percentage of lung attenuation area with values <− 856 Hounsfield Units at expiratory CT scan, PEF = Peak expiratory flow, %pLDA = percentage of persistent low density area, %pred = percentage of predicted, PRISm = Preserved Ratio Impaired Spirometry, i.e. FEV₁/FVC ≥ 0.7 and post-bronchodilator FEV₁ < 80% of predicted; ^a parameters calculated by using VIDA software; ^b parameters calculated by using Imbio software

ISSN: 1465-993X