Fig. 2

Schematic representation of study protocol for cohort 2. At weaning, male WT and ST2^−/− pups were placed in cages with other mice of the same genotype. Each cage was assigned to either chow or HFD. Prior to (not shown) and after 4, 8, and 12 weeks on the diet mice were fasted overnight. A tail nick was then performed for the assessment of fasting blood glucose. After 10 weeks and 14 weeks on the diet, a mandibular blood draw was performed for the assessment of metabolic hormones and serum cytokines and chemokines, respectively