Fig. 6

Effect of a miR-451 inhibitor on vascular remodeling shown using elastin staining and quantification of arterial wall thickness. Representative images of tissues obtained from NB WT RA (a), WT BPD (b), miR-451 inhibitor treated RA (c) and BPD animals (d) prepared with Verhoeff’s stain are shown to demonstrate changes in elastin deposition. Inset: vessel wall in high magnification (X400). Quantification of the mean arterial wall thickness in the four experimental groups is shown in (e). Each column is representative of data obtained from a minimum of 4 animals. * p < 0.05; ** p < 0. 01, *** p < 0.001 Scale Bar: 100 μm