Endothelial dysfunction is not a predictor of outcome in chronic obstructive pulmonary disease

Respiratory Research

Table 1 Baseline characteristics of the patients included in the study

Parameter	COPD patients (n = 157) n (%); median (IQR)
Male	108 (69)
Age (years)	67 (59–73)
Current smoker	65 (42)*
Pack years	53.1 (25)
BMI (kg/m²)	26 (23–31)
BODE Index	2 (3)
6MWT (m)	420 (154)
Exacerbation rate	1 (0)
Pulse (bpm)	74 (67–83)
Systolic blood pressure (mmHg)	133 (121–146)
Diastolic blood pressure (mmHg)	74 (63–82)
Unadjusted Charlson Score	2 (2)^c
MMRC score	2 (1)^a
COPD Assessment Score	16 (10)^b
Lung function
FEV₁ (L)	1.3 (0.9–1.7)^d
FVC (L)	2.8 (2.3–3.4) ^d
FEV₁, % predicted	52.7 (40.1–65.6) ^d
FVC, % predicted	82.3 (71.8–99.6) ^d
TLC (L)	6.7 (5.6–7.8)^e
TLC, % predicted	111.0 (98.3–129.6)^e
DLCO_SB (mmol/min/kPa)	4.5 (3.6–5.8)^a
DLCO_SB, % predicted	56.7 (46.5–69.8)^a
DLCO/VA (mmol/min/kPa)	0.91 (0.74–1.16)^a
DLCO/VA, % predicted	66.3 (54.3–87.7)^a
SGRQ
Symptom score	42.5 (24.7–67.0)
Activity score	53.8 (41.4–71.0)
Impact score	19.5 (12.7–36.6)
Total score	34.2 (23.7–51.5)
Imaging: CT-scans	126 (80)
Emphysema	94 (75)
Centrilobular emphysema	79 (84)
Paraseptal emphysema	20 (21)

BMI Body mass index, BODE BMI, airflow obstruction, dyspnea and exercise capacity, 6MWD 6-min walk distance, MMRC Modified Medical Research Council, FEV₁ Forced expiratory volume in 1 s., FVC Forced vital capacity, TLC Total lung capacity, DLCO Diffusing capacity of the lung for carbon monoxide, SGRQ St. George’s Respiratory Questionnaire *2 missing values; ^a 7 missing values; ^b 21 missing values; ^c 22 missing values; ^d 1 missing value; ^e 7 missing values

ISSN: 1465-993X