Table 2 Primary Outcomes and change in pulmonary function tests: Baseline mean SGRQ, HADS, and PHQ-9 scores and pulmonary function tests with mean change at 3 and 6 months
|  | Baseline | 3 months | 6 months | |||||
|---|---|---|---|---|---|---|---|---|
UC N = 11 Mean, (SD) | UC + PC N = 11 Mean, (SD) | UC N = 9Mean Change, (SD) | UC + PC N = 9Mean Change, (SD) | p | UC N = 9Mean Change, (SD) | UC + PC N = 9Mean Change, (SD) | p | |
SGRQ Total | 41.1 (16.8) | 43 (24.4) | −3.6 (10.3) | + 5.2 (12.7) | 0.097 | + 0.1 (12.3) | + 3.8 (11.9) | 0.44 |
SGRQ Impact | 27.7 (16.6) | 38.4 (29.1) | −2.2 (12.8) | + 1.1 (19.6) | 0.69 | + 0.9 (14.4) | −1.6 (23.4) | 0.99 |
SGRQ Activity | 57.5 (21.1) | 61.1 (28.8) | −3.4 (13.6) | + 2.4 (11.7) | 0.32 | + 2.6 (14.4) | + 1.8 (12.1) | 0.94 |
SGRQ Symptoms | 53.6 (21.6) | 42.7 (21.7) | −7.8 (23.9) | + 10.7 (10.6) | 0.066 | −6.0 (15.2) | + 4.6 (5.5) | 0.055 |
HADS(A) | 4.3 (3.3) | 6.3 (5.1) | −0.4 (2.9) | + 0.3 (2.4) | 0.59 | + 0.4 (3.2) | −0.8 (2.3) | 0.35 |
HADS(D) | 4.1 (2.9) | 3.9 (3.6) | −0.3 (2.5) | + 0.4 (0.0) | 0.49 | + 0.7 (1.9) | + 0.7 (2.2) | 0.99 |
PHQ-9 | 6.5 (3.3) | 4.4 (6.8) | −1.6 (1.7) | + 0.9 (1.8) | 0.008 | −0.7 (3.5) | + 2.1 (2.4) | 0.26 |
FVC (% predicted) | 72.9% (18.7%) | 73.9% (19.8%) | + 1.5% (5.1%) | + 1.0% (6.4%) | 0.83 | + 0.2% (6.0% | −4.1% (9.0%) | 0.36 |
TLC (% predicted) | 65.4% (7.2%) | 71.4% (8.9%) | + 3.3% (9.2%) | −7.0% (3.0%) | 0.040 | + 1.3% (6.7%) | −14.7% (4.5%) | 0.001 |
DLCO (% predicted) | 54.9% (14.2%) | 57.8% (13.9%) | −1.4% (5.4%) | −5.1% (7.0%) | 0.34 | −4.0% (5.3%) | −2.3% (6.5%) | 0.73 |