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Table 3 Demographic, clinical and functional data and biomarker assessment of sarcoidosis patients in relation to High resolution computed tomography (HRCT) evidence of involvement

From: Chitotriosidase: a biomarker of activity and severity in patients with sarcoidosis

 No lung involvementLymph node + micronodularMacronodular and consolidationLung fibrosisP-value
N° (%)27 (11.8)127 (55.9)62 (27.1)12 (5.6) 
Male (%)10 (39)59 (46)26 (42)2 (16)0.2063
Age yrs57.6 ± 10.155.1 ± 12.757.3 ± 12.253.2 ± 12.70.5185
Smoking history (pack/year)7.2 ± 11.73.8 ± 93.7 ± 9.18.2 ± 13.40.4052
 • Current (%)3 (11)7 (5)3 (5)00.5357
 • Former (%)8 (29)37 (29)24 (38)3 (25)0.5357
 • Never (%)16 (59)82 (65)35 (56)9 (75)0.5357
Biomarkers determination (basal sampling)
 • Chitotriosidase nmol/ml/h196.7 ± 150.9284.2 ± 355.2132.3 ± 119.7666.3 ± 3110.0005
 • ACE UI/ml51.4 ± 22.363.7 ± 31.350.1 ± 17.961.6 ± 26.10.0047
 • Lysozyme mg/dl4.5 ± 1.75.9 ± 2.25.1 ± 1.86.5 ± 2.40.0033
PFTs
 • FVC l (%)3.6 ± 0.9 (107 ± 18)3.4 ± 1.1 (100 ± 19)3.5 ± 1.1 (108 ± 15.3)2.7 ± 1.1 (79.3 ± 15.8)<0.0001
 • FEV1 l (%)2.8 ± 0.8 (100.7 ± 18.7)2.6 ± 0.9 (93.3 ± 19.8)2.6 ± 0.9 (94 ± 15.6)2.1 ± 0.8 (74.5 ± 17.3)0.0013
 • FEV1/FVC77.2 ± 5.876.2 ± 8.675.1 ± 578.1 ± 8.20.3125
 • TLC l (%)6.2 ± 1.3 (109 ± 15.8)6 ± 1.5 (105 ± 16.7)6.2 ± 1.4 (115.4 ± 18.5)4.6 ± 1.6 (91.5 ± 17.2)0.0575
 • DLCO %85.3 ± 16.177.5 ± 14.979.5 ± 17.650.4 ± 16.2<0.0001
 • KCO %96.3 ± 13.591.6 ± 19.389.2 ± 15.674.7 ± 17.80.0026
Clinical assessment
 • No symptoms (%)18 (66)44 (35)17 (27)2 (16)0.0018
 • Cough (%)3 (11)36 (28)16 (26)4 (33)0.2981
 • Dyspnea (%)4 (15)54 (43)21 (34)8 (66)0.0074
 • Asthenia (%)4 (15)39 (31)16 (26)5 (41)0.2497
 • Arthtralgia (%)2 (7)32 (25)25 (40)4 (33)0.0118
Clinical onset
 • Asymptomatic (%)24 (89)72 (57)47 (76)10 (83)0.0017
 • Lofgren syndrome (%)1 (3)8 (6)4 (6)00.7808
Clinical phenotypes
 • Abdominal (%)1 (3)14 (11)1 (1.6)2 (16)0.5170
 • OCCC (%)2 (7)7 (5)3 (5)00.5170
 • Muscoloskeletal-cutaneous (%)3 (11)16 (12.6)9 (14)1 (8)0.5170
 • Isolated pulmonary (%)21 (77)88 (69.2)48 (77)9 (75)0.5170
 • Extrapulmonary (%)02 (1.5)1 (1.6)0 
COS classification19955110 
 • 1 (%)4 (21)1 (1)000.0002
 • 2 (%)3 (16)3 (3)000.0002
 • 3 (%)2 (10)3 (3)000.0002
 • 4 (%)2 (10)3 (3)3 (6)00.0002
 • 5 (%)1 (5)4 (4)3 (6)00.0002
 • 6 (%)1 (5)9 (9)9 (17)2 (20)0.0002
 • 7 (%)4 (21)26 (21)10 (19)1 (10)0.0002
 • 8 (%)2 (10)36 (36)22 (43)5 (50)0.0002
 • 9 (%)011 (11)4 (8)2 (20)0.0002
  1. OCCC ocular-cardiac-cutaneous-central nervous system