Table 4 Univariate and multivariate analyses of the hazard ratios (HRs) among Stage III and stage IV long-term survivors

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Age

1.03 (0.98-1.08)

0.29

1.00 (0.94-1.06)

0.91

1.01 (0.99-1.04)

0.29

1.00 (0.98-1.03)

0.74

 Male

0.73 (0.26-2.03)

0.54

1.27 (0.38-4.19)

0.70

0.65 (0.35-1.21)

0.17

1.00 (0.41-2.42)

0.99

 Female (ref)

 Current

0.28 (0.09-0.89)

0.23 (0.04-1.22)

0.47 (0.23-0.99)

0.36 (0.13-1.01)

 Previous

0.53 (0.29-0.94)

0.03

0.48 (0.21-1.11)

0.09

0.69 (0.48-0.995)

0.047

0.60 (0.36-1.01)

0.052

 Never (ref)

 1

0.63 (0.25-1.60)

0.33

0.96 (0.31-2.94)

0.94

1.75 (0.94-3.24)

0.08

1.45 (0.70-3.01)

0.31

 BMI

1.03 (0.91-1.17)

0.62

1.02 (0.91-1.15)

0.73

1.10 (0.99-1.21)

0.07

1.14 (1.01-1.29)

0.04

 Primary tumor      diameter (mm)

1.02 (0.99-1.04)

0.18

1.03 (0.99-1.06)

0.11

1.04 (1.02-1.07)

< 0.01

1.04 (1.02-1.07)

< 0.01

 N3

2.32 (0.34-15.9)

1.77 (0.13-23.7)

3.50 (1.33-9.20)

1.87 (0.59-5.93)

 N2

1.75 (0.49-6.33)

1.46 (0.26-8.25)

2.31 (1.21-4.39)

1.52 (0.70-3.28)

 N1

1.32 (0.70-2.52)

0.39

1.21 (0.51-2.87)

0.67

1.52 (1.10-2.10)

0.01

1.23 (0.84-1.81)

0.29

 M factor

-

-

 M1c

0.87 (0.37-2.04)

0.74 (0.30-1.85)

 M1b

0.93 (0.61-1.43)

0.74

0.86 (0.55-1.36)

0.52

 Total metastatic number at initial diagnosis

-

-

1.09 (1.01-1.18)

0.03

1.11 (1.002-1.23)

0.045