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Table 4 Event rates and odds ratios* for readmission and mortality within 365 days in patients with asthma following an acute hospitalization, stratified by blood eosinophil count (n = 1268)

From: The biomarkers suPAR and blood eosinophils are associated with hospital readmissions and mortality in asthma – a retrospective cohort study

Follow-up

Variable

Readmission

Mortality

Analysis

Eosinophils

Events (%)

OR (95% CI)

P-value

Events (%)

OR (95% CI)

P-value

30 days

Continuous

 

0.98 (0.9–1.1)

0.64

 

0.77 (0.5–1.1)

0.137

Adjusted

Low

87 (19.2%)

1

 

14 (3.1%)

1

 

Medium

45 (19.0%)

0.99 (0.7–1.5)

0.94

1 (0.4%)

0.26 (0.03–2.1)

0.21

High

47 (14.1%)

0.75 (0.5–1.1)

0.16

3 (0.9%)

0.73 (0.2–2.9)

0.65

Total events§

179 (40.6%)

  

18 (33.3%)

  

90 days

Continuous

 

0.95 (0.9–1.0)

0.21

 

0.79 (0.6–1.0)

0.035

Adjusted

Low

129 (28.5%)

1

 

26 (5.8%)

1

 

Medium

75 (31.6%)

1.15 (0.8–1.6)

0.43

5 (2.1%)

0.48 (0.2–1.5)

0.21

High

68 (20.4%)

0.66 (0.5–0.9)

0.019

4 (1.2%)

0.41 (0.1–1.3)

0.12

Total events§

272 (61.7%)

  

35 (64.8%)

  

365 days

Continuous

 

0.94 (0.9–1.0)

0.11

 

0.70 (0.6–0.9)

0.001

Adjusted

Low

207 (45.8%)

1

 

41 (9.1%)

1

 

Medium

113 (47.7%)

0.99 (0.7–1.4)

0.94

8 (3.4%)

0.42 (0.2–1.0)

0.061

High

121 (36.2%)

0.64 (0.5–0.9)

0.0051

5 (1.5%)

0.25 (0.09–0.7)

0.008

Total events§

441 (100%)

  

54 (100%)

  
  1. *Multivariable adjusted analyses included age, sex, Charlson comorbidity score, suPAR and CRP
  2. Shown as number of patients with event (percentage out of total patient population in each group of blood eosinophil count (low, medium, high) at 365 days)
  3. Only patients with a minimum of 365 days follow-up included in analyses (n = 1068)
  4. Cut-offs defined as Low (< 150 cells/μL, n = 452), Medium (150–300 cells/μL, n = 237), and High (> 300 cells/μL, n = 334)
  5. §Total number of events at follow-up as a percentage of number of events at 365 days
  6. CRP – C-Reactive Protein
  7. CI – Confidence Interval
  8. OR – Odds Ratio
  9. suPAR – Soluble Urokinase Plasminogen Activator Receptor