Fig. 1
From: DNA methylation is associated with lung function in never smokers
Manhattan and forest plots of the meta-analysis on four independent epigenome-wide association studies on FEV1/FVC in never smokers. a Manhattan plot in which every dot represents an individual CpG-site. Location on the X-axis indicated the chromosomal position and location on the Y-axis indicates the inversed log [10] p-value of the meta-analysis. Dotted horizontal line indicates p-value of 0.0001, horizontal fixed line indicates epigenome-wide significance (p-value < 0.05/396,243 = 1.26 × 10^− 7). b-d Forest plots showing the effect estimates and standard errors of the 4 independent EWA studies and meta-analysis for the top hits cg10012512 (b), cg028885771 (c) and cg25105536 (d)