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Table 1 Characteristics of enrolled patients. Continuous variables are presented as medians (with interquartile ranges), and categorical variables are presented as N (%)

From: Metagenomic identification of severe pneumonia pathogens in mechanically-ventilated patients: a feasibility and clinical validity study

 

Culture-Positive

Pneumonia

Culture-Negative

Pneumonia

Controls

N

9

5

8

Age, median [IQR], yrs

58.3 [55.2, 62.6]

55.8 [45.7, 62.8]

61.2 [51.9, 67.4]

Male, N (%)

5 (55.6)

2 (40.0)

6 (75.0)

BMI, median [IQR]

24.0 [21.5, 34.6]

31.2 [25.6, 32.9]

28.1 [25.1, 36.1]

SOFA Score, median [IQR]a

6.0 [4.0, 6.0]

7.0 [6.0, 7.0]

5.0 [4.0, 8.0]

PaO2:FIO2 ratio, median [IQR], mmHg

158.0 [137.0, 275.0]

150.0 [121.0, 208.0]

221.5 [205.0, 319.5]

Heart rate (median [IQR]), beats per minute

107.0 [92.0, 117.0]

83.0 [82.0, 88.0]

81.5 [73.8, 85.5]

SBP (median [IQR]) mmHg

125.0 [102.0, 141.0]

118.0 [117.0, 127.0]

105.0 [97.8, 117.5]

WBC, median [IQR], ×  109 per liter (L)

10.0 [7.4, 16.8]

4.6 [3.5, 8.3]

5.4 [4.5, 11.6]

Platelets, median [IQR], × 109 per liter (L)

190.0 [169.0, 281.0]

155.0 [136.0, 210.0]

141.0 [72.2, 171.0]

Creatinine, median [IQR], mg/dL

1.3 [1.1, 1.5]

1.5 [1.5, 2.0]

1.0 [0.8, 1.4]

Respiratory Rate, median [IQR], 1/min

22.0 [21.0, 24.0]

21.0 [20.0, 24.0]

17.0 [15.5, 17.2]

PEEP, median [IQR], cm

8.0 [5.0, 8.0]

5.0 [5.0, 8.0]

5.0 [5.0, 5.8]

Tidal Volume (per kg of PBW), (median [IQR]), ml/kg

6.8 [6.2, 8.4]

6.2 [6.1, 6.6]

6.3 [6.0, 7.1]

Plateau Pressure, median [IQR], cm

20.0 [13.0, 23.5]

25.0 [21.0, 29.0]

16.0 [13.0, 21.5]

Type of mechanical breaths, n (%)b

 Volume control

7 (77.8)

4 (80.0)

8 (100)

 Pressure control

2 (22.2)

1 (20.0)

0 (0)

Ventilator free days, median [IQR], days

12.0 [0.0, 23.0]

17.0 [6.0, 23.0]

24.5 [24.0, 26.0]

ICU Length of Stay, median [IQR], days

8.0 [5.0, 18.0]

11.0 [6.0, 12.0]

4.5 [3.8, 5.0]

Acute Kidney Injury, N (%)

8 (88.9)

4 (80.0)

2 (25.0)

30 Day Mortality, N (%)

3 (33.3)

1 (20.0)

1 (12.5)

On antibiotic therapy, N (%)

9 (100)

5 (100)

5 (62.5)

Antibiotic days, median [IQR], days

12.0 [10.0, 24.0]

21.0 [20.0, 24.0]

3.5 [0.0, 7.5]

CPIS, median [IQR],

8.0 [7.0, 9.0]

6.0 [5.0, 7.0]

5.0 [4.0, 5.2]

Procalcitonin, median [IQR], pg/μl

2783.0 [1049.5, 4330.1]

4866.0 [94.4, 4965.1]

353.5 [250.4, 1531.6]

  1. Abbreviations: IQR Interquartile range, BMI Body mass index, SOFA Sequential organ failure assessment, PaO2 Partial pressure of arterial oxygen, FiO2 Fractional inhaled concentration of oxygen, SBP Systolic blood pressure, WBC White blood cell count, PEEP Positive end-expiratory pressure, PBW Predicted body weight, ICU Intensive care unit, CPIS Clinical pulmonary infection score
  2. a SOFA score calculation does not include the neurologic component of SOFA score because all patients were intubated and receiving sedative medications, impairing our ability to perform assessment of the Glasgow Coma Scale in a consistent and reproducible fashion
  3. b All patients were on assist controls mode of ventilation at time of sample acquisition
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Respiratory Research

ISSN: 1465-993X

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