The association of cognitive functioning as measured by the DemTect with functional and clinical characteristics of COPD: results from the COSYCONET cohort

Table 3 Dependence of DemTect score in original form on clinical and functional parameters

	Unstandardized regression coefficient	SEM	95% Confidence Interval		p-value
	Unstandardized regression coefficient	SEM	Lower limit	Upper limit	p-value
Age ≥ 60 y *	1.765	0.222	1.330	2.199	< 0.001
Female	1.243	0.138	0.971	1.515	< 0.001
Age [y]	−0.079	0.012	−0.103	− 0.056	< 0.001
Current smoker	0–.444	0.138	−0.733	− 0.156	0.003
Diagnosis of CI	−0.617	0.279	−1.164	−0.069	0.027
mMRC	0.197	0.091	0.019	0.376	0.030
SGRQ impact score	−0.009	0.004	−0.017	− 0.002	0.015
6-MWD [m]	0.002	0.001	0.000	0.004	0.010
log₁₀CRP [mg/100 mL]	− 0.350	0.021	−0.583	− 0.116	0.003
FVC [%predicted]	0.006	0.004	−0.002	0.013	0.135
CaO₂ [mL/100 mL]	0.090	0.039	0.014	0.167	0.020

The table shows the results of multivariable linear regression analyses in terms of the unnormalized regression coefficients as well as 95%-confidence intervals. The level of significance was set at p < 0.05. *Indicator variable with values 0 and 1 for ages < and ≥ 60 years of age, respectively. CRP values were included as log₁₀-transformed values, therefore the respective coefficient must be interpreted as change in the respective DemTect score for a tenfold increase in CRP level (log₁₀(10) = 1). CI = cognitive impairment. When repeating the same analysis while including the activity and symptom scores of the SGRQ, these turned out to be not statistically significant predictors (p = 0.247 and p = 0.127, respectively), while the impact score remained significant (p = 0.0013)

ISSN: 1465-993X