Table 1 Summary of study characteristics. Detailed summary of information extracted from included studies
Author (year) | Study Design | Animal Characteristics | Intervention Characteristics | Primary Outcome | Secondary Outcomes | |||
|---|---|---|---|---|---|---|---|---|
Disease | Disease | Animal | Age | Source; | Dose; | Inflammation | Lung | |
Model | Induction | Model; Gender | Â | (Origin) | Delivery; Timing; Frequency | Architecture/Function | ||
 Ionescu (2012) | ARDS | IT injection of 4 mg/kg LPS (E. coli 055:B5) | C57/BL6 mice; Male | Adult | Bone Marrow | 30 μl; IT; 4 h post-LPS exposure; once | Cytokines | Lung sections |
 Lu (2015) | ARDS | Oropharyngeal aspiration 2 mg/kg LPS (E. Coli 0127:B8) | C57/BL6 mice; Male | Not Reported | Adipose Tissue | 200 μl; IV tail vein; 4 h post-LPS exposure; once | TNF-alpha; IL-6; MIP-2; IL-10; VEGF | Alveolar wall sections |
 Wakaya-ma (2015) | ARDS | 6 U/kg Bleomycin | C57/BL6J mice; Female | Adult | Human Exfoliated Deciduous Teeth | 500 μl; IV jugular vein; 24 h post-bleomycin exposure; once | Cell surface markers; Cytokines | Fibrotic lung sections |
 Ahmadi (2016) | Asthma | IP administered OVA on days 1 and 8; day 14, exposure to 4% OVA nebulizer for 5 min for 18+/−1 days | Wistar rats; Male | Adult | Bone Marrow | 50 μl; IV left femoral vein; 1 day post sensitization; once | CD3+; CD4+; CD8+ |  |
 Ahmadi (2017) | Asthma | IP administered OVA on days 1 and 8; day 14, 5 min exposure to 4% OVA nebulizer for 18+/−1 days | Wistar rats; Male | Adult | Bone Marrow | 50 μl; IT; 1 day post sensitization; once | IL-4; IL-10 | Emphysema;Atelectasis; Hyperemia; Epithelialization; Leukocyte Infiltration |
 Cruz (2015) | Asthma | 5 μg Aspergillus fumigatus days 0 and 7 for sensitization; same inoculation on days 14 and 16 for challenge | C57/BL6 mice; Male | Adult | Bone Marrow | 200 μl; IV tail vein; day 14 after aspergillus challenge; once | Neutrophils; Eosinophils; Macrophages; Lymphocytes; Cytokines | Lung sections; Airway resistance; Tissue resistance; lung elasticity |
 Aslam (2009) | BPD | Exposure to 75% O2 within 24 h of birth | FVB mice; male/female | Neonate | Bone Marrow | 50 μl; IV superficial temporal vein; postnatal day 4; once | Macrophage; Neutrophils, Cytokines | Pulmonary arteriole; Lung alveoli; Medial wall thickness |
 Sutsko (2012) | BPD | 2 weeks 90% O2 exposure | Sprague-Dawley rats; male/female | Neonate | Bone Marrow | 50 μl; IT; postnatal day 9; once | IL-6/18 s; IL-1B/18 s; TTF-1/18 s; VEGF; angiopoietin-1 | Alveolarization; lung vascular density |
 Lee (2012) | PH | 8.5 ± 0.5% O2 exposure for 48 h | FVB mice; gender not reported | Adult | Bone Marrow | 50 μl; IV left jugularvein; before 48 h hypoxia induction; once | MCP-1; FIZZ-1/HIMF |  |
 Rathinas-abapathy (2016) | PH | 50 mg/kg Monocrotaline | Sprague-Dawley rats; Male | Adult | Adipose Tissue | 100 μl; IV jugular vein;14 days post-MCT exposure; once | Cell surface markers; Cytokines | Pulmonary vesselwall thickness; RV fibrosis |