Fig. 4
From: Inhibition of Aurora A enhances radiosensitivity in selected lung cancer cell lines
Irradiation enhancement of MLN8237 in p53 expressing NSCLC cell lines. a Radio-sensitization of lung cancer cells by MLN8237. HCC2429 (Left), H460 (Middle) and H1299 (right) cells were treated with 100 nM MLN8237 or DMSO for 2 h followed by irradiation with the indicated doses. Forty-eight hours after radiation, drug-containing media was replaced with fresh media. After 8–12 days, surviving colonies were stained and scored. Shown are survival curves containing the mean ± SD of three separate, repeated experiments. b Caspase 3 cleavage after MLN8237, radiation or combination treatment