Fig. 1From: Protein phosphatase 2A (PP2A): a key phosphatase in the progression of chronic obstructive pulmonary disease (COPD) to lung cancerp38 MAPK inflammatory signalling is regulated by PP2A. p38 MAPK activates MK2, subsequently mediating the phosphorylation and thereby the inactivation of TTP. Inactive TTP allows for the stabilisation of pro-inflammatory cytokine mRNA and thus sustained inflammation. In response to sustained inflammation, MKP-1 acts as a negative feedback effector, dephosphorylating and thereby inactivating p38 MAPK, and inhibiting downstream pro-inflammatory signalling. PP2A dephosphorylates and activates TTP. Active TTP degrades pro-inflammatory cytokine mRNA by binding to the ARE 3′ untranslated region, resulting in the suppression of inflammationBack to article page