Table 2 Top proteins with higher or lower levels in participants with IPF versus controls. Proteins with a |log₂FC| > 0.585 (i.e. a > 1.5-fold difference in protein concentration between groups) and a false discovery rate (FDR)-corrected p Value < 0.05 are shown

 PGAM1

Phosphoglycerate mutase 1

9.00E-08

9.24E-07

 GPD1

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

4.95E-19

3.08E-17

 THBS1

Thrombospondin-1

1.46E-16

6.55E-15

 VWF

von Willebrand factor

3.68E-32

1.20E-29

 CCL17

C-C motif chemokine 17

2.38E-16

1.03E-14

 BPI

Bactericidal permeability-increasing protein

7.26E-15

2.37E-13

 OLR1

Oxidised low-density lipoprotein receptor 1

4.84E-32

1.26E-29

 CAPG

Macrophage-capping protein

1.09E-28

1.43E-26

 SPARC

SPARC

3.13E-15

1.13E-13

 FN1

Fibronectin

1.19E-30

2.59E-28

 PF4

Platelet factor 4

7.84E-08

8.32E-07

 PPBP

Connective tissue-activating peptide III

2.74E-08

3.26E-07

 PPBP

Neutrophil-activating peptide 2

3.23E-08

3.73E-07

 ICAM5

Intercellular adhesion molecule 5

4.10E-34

1.78E-31

 CXCL13

C-X-C motif chemokine 13

1.63E-15

6.27E-14

 PGD

6-phosphogluconate dehydrogenase, decarboxylating

7.64E-07

6.39E-06

 C1R

Complement C1r subcomponent

3.39E-29

5.49E-27

 HIST1H1C

Histone H1.2

1.58E-07

1.56E-06

 MMP9

Matrix metalloproteinase-9

4.49E-16

1.83E-14

 SFTPD

Pulmonary surfactant-associated protein D

1.75E-08

2.20E-07

 GDF15

Growth/differentiation factor 15

2.32E-28

2.75E-26

 S100A9

Protein S100-A9

9.08E-18

4.74E-16

 FN1

Fibronectin fragment 3

3.78E-29

5.49E-27

 PDGFB

Platelet-derived growth factor subunit B

7.67E-08

8.25E-07

 CCL18

C-C motif chemokine 18

2.31E-29

4.31E-27

 ANXA6

Annexin A6

3.36E-09

4.82E-08

 MMP1

Matrix metalloproteinase-1

3.92E-11

8.25E-10

 TIMP3

Metalloproteinase inhibitor 3

4.04E-10

7.32E-09

 VAV1

Proto-oncogene vav

8.31E-05

4.15E-04

 HNRNPA2B1

Heterogeneous nuclear ribonucleoproteins A2/B1

2.27E-12

5.69E-11

 PDGFA

Platelet-derived growth factor subunit A

3.05E-08

3.55E-07

 APP

Amyloid-beta A4 protein

1.34E-11

2.97E-10

 S100A6

Protein S100-A6

4.47E-14

1.33E-12

 CCL5

C-C motif chemokine 5

3.43E-07

3.15E-06

 C4A C4B

Complement C4A and C4B

1.13E-08

1.49E-07

 CCL22

C-C motif chemokine 22

6.96E-18

3.95E-16

 HK2

Hexokinase-2

2.22E-09

3.35E-08

 MMP3

Stromelysin-1

2.77E-36

1.81E-33

 CKB CKM

Creatine kinase B-type; Creatine kinase M-type

4.95E-22

4.04E-20

 ADSL

Adenylosuccinate lyase

2.70E-26

2.93E-24

 SHH

Sonic hedgehog protein

7.35E-26

7.38E-24

 CA6

Carbonic anhydrase 6

2.15E-15

8.01E-14

 AGER

Advanced glycosylation end product-specific receptor

5.74E-20

3.74E-18

 HSPB1

Heat shock protein beta-1

1.46E-05

9.18E-05

 TFF1

Trefoil factor 1

1.20E-12

3.20E-11

 PRKCA

Protein kinase C alpha type

3.68E-04

1.54E-03

 PRKACA

cAMP-dependent protein kinase catalytic subunit alpha

7.02E-05

3.63E-04