Fig. 5

Change in 6-Minute Walk Distance and NT-proBNP from Baseline at Week 24 by WHO Functional Class and Treatment Group (Primary Analysis Set). a 6 Minute Walk. Error bars represent 95% confidence intervals. Stratified Wilcoxon Rank Sum analysis: worst rank scores were used for missing data following death or adjudicated hospitalization; otherwise, last observation carried forward imputation was used. FC = functional class; WHO=World Health Organization. b NT-pro BNP. Error bars represent 95% confidence intervals. Geometric mean ratio estimates from Mixed Models Repeated Measures analysis adjusted for randomization stratification factors and baseline value, with no imputation for missing data. Terms in model: Treatment, Baseline value, Visit, Treatment x Visit, Etiology of PAH (stratification value) and WHO functional class (stratification value). Stratification values may differ from baseline subgroup values. This is a post-hoc analysis