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Table 6 Adjusted mean annual direct and indirect costs of GOLD Grades – Extended model

From: Direct and indirect costs of COPD progression and its comorbidities in a structured disease management program: results from the LQ-DMP study

 

GOLD grade 1

GOLD grade 2

GOLD grade 3

GOLD grade 4

N

Mean (CI 95%)

N

Mean (CI 95%)

N

Mean (CI 95%)

N

Mean (CI 95%)

Total direct costs

12,053 (30.7%)

€3828 [€3706–€3954]

18,119 (46.1%)

€4295 [€4185–€4407]***

7383 (18.8%)

€5540 [€5323–€5769]***

1752 (4.5%)

€8779 [€7982–€9649]***

Ambulatory costs

12,053 (30.7%)

€554 [€533–€577]

18,119 (46.1%)

€597 [€575–€619]**

7383 (18.8%)

€595 [€566–€626]*

1752 (4.5%)

€615 [€546–€697]

Medication costs

12,053 (30.7%)

€590 [€568–€613]

18,119 (46.1%)

€718 [€690–€748]***

7383 (18.8%)

€939 [€888–€1001]***

1752 (4.5%)

€1498 [€1208–€1852]***

Hospitalization

12,053 (30.7%)

€2068 [€1969–€2170]

18,119 (46.1%)

€2271 [€2189–€2355]**

7383 (18.8%)

€2943 [€2784–€3112]***

1752 (4.5%)

€4316 [€3850–€4781]***

Rehabilitation costs

12,053 (30.7%)

€126 [€113–€138]

18,119 (46.1%)

€145 [€134–€156]*

7383 (18.8%)

€183 [€163–€205]***

1752 (4.5%)

€275 [€226–€325]***

Remedies

12,053 (30.7%)

€394 [€378–€411]

18,119 (46.1%)

€421

[€407–€435]*

7383 (18.8%)

€632 [€601–€664]***

1752 (4.5%)

€1185 [€1086–€1287]***

Travel costs

12,053 (30.7%)

€114 [€106–€123]

18,119 (46.1%)

€131 [€123–€138]**

7383 (18.8%)

€196 [€183–€210]***

1752 (4.5%)

€319 [€278–€361]***

Total indirect costs

3705 (31.0%)

€11,739 [€11,208-12,280]

5473 (45.7%)

€12,984 [€12,523–€13,443]***

2160 (18.1%)

€16,117 [€15,312–€16,922]***

632 (5.3%)

€20,525 [€18,822–€22,287]***

Sick day costs

3705 (31.0%)

€2983 [€2789–€3183]

5473 (45.7%)

€3145 [€2968-33,329€]

2160 (18.1%)

€3210 [€2924–€3496]

632 (5.3%)

€3255 [€2668–€3900]

Premature retirement costs

3705 (31.0%)

€8972 [€8497–€9449]

5473 (45.7%)

€9715 [€9315–€10,108]*

2160 (18.1%)

€12,449 [€11,792–€13,130]***

632 (5.3%)

€16.180 [€14,936–€17.443]***

  1. Significant differences between GOLD grade 1 and the other groups:* p < 0.05 ** p < 0.01 *** p < 0.001.
  2. Confidence intervals and p-values of the cost differences were derived by bootstrapping the original data set with 5000 bootstraps [17]
  3. bold: p > 0.05