Table 3 Parameter estimates (analogous to Table 2) for the regression analyses for the subgroups of “true placebos” and “ICS-placebos”
Parameter | Estimate | Implied annual percentage change | Pb |
|---|---|---|---|
True placebos (21 studies): | |||
Rate intercept β0 | 0.440 (− 0.034, 0.912) | ||
Rate slope β1 (publication year) | −0.079 (− 0.132, − 0.026) | − 7.553 (− 12.356, − 2.606) | 0.006 |
Rate random effect σλ | 0.517 (0.356, 0.787) | ||
Overdispersion mean μφ | −5.139 (− 9.011, − 0.708) | ||
Overdispersion random effect σφ | 0.667 (0.031, 2.263) | ||
ICS-placebos (34 studies): | |||
Rate intercept β0 | 0.440 (−0.034, 0.912) | ||
Rate slope β1 (publication year) | −0.079 (− 0.132, − 0.026) | −7.553 (− 12.356, − 2.606) | < 0.001 |
Rate random effect σλ | 0.517 (0.356, 0.787) | ||
Overdispersion mean μφ | −5.139 (− 9.011, − 0.708) | ||
Overdispersion random effect σφ | 0.667 (0.031, 2.263) | ||