Table 6 Univariate and multivariate analyses comparing characteristics of cases and controls with local LC

 Gender (male), n (%)

31 (83.7)

65 (78.3)

0.330

 Age, mean (SD)

65.5 (12.9)

64.6 (9.4)

0.680

 BMI, mean (SD)

27.7 (4.3)

27.3 (4.5)

0.510

 Laboral exposure, n (%)

15 (40.5)

25 (30.1)

0.390

 Tobacco history, n (%)

37 (100)

82 (98.8)

0.690

 Active smokers, n (%)

20 (54.1)

45 (54.2)

0.340

 Pack-years, mean (SD)

45.9 (24)

47.5 (25)

0.750

 GOLD I-II, n (%)

5 (13.5)

66 (79.5)

0.260

 GesEPOC A (%)

35 (94.6)

80 (96.4)

0.490

 Bodex, mean (SD)

0.9 (1.50)

0.8 (1.2)

0.700

 CAT, mean (SD)

8.5 (3)

9.7 (7.6)

0.570

 FEV₁(%), mean (SD)

71.6 (21.3)

71 (20.2)

0.880

 DLCO(%),mean (SD)

72.6 (22)

70.4 (22.6)

0.660

 Charlson index, mean (SD)

1.3 (1.9)

0,7 (1)

0.010

 TNF-α (pg/ml), mean (SD)

11.6 (21)

9.3 (7.4)

0.530

 IL-6 (pg/ml), mean (SD)

6.5 (6.1)

6.2 (12.1)

0.850

 IL-8 (pg/ml), mean (SD)

22.1 (46.4)

19.2 (28.8)

0.740

 Leukocytes (per μl), mean (SD)

8880.9 (4039.1)

7706.1 (2334)

0.110

 Lymphocytes (per μL),mean (SD)

2744.9 (3190.1)

2398.5 (965.7)

0.370

 Neutrophils (per μl), mean (SD)

5491.1 (2324.7)

4464.2 (2136.7)

0.020

 NLR, mean (SD)

2.9 (1.9)

2.1 (1.5)

0.030

 Platelets (per μl), mean (SD)

273,594.6 (132,871.4)

243,402.4 (72,978.9)

0.270

 MPV (fl), mean (SD)

8.4 (1.3)

8.9 (1)

0.040

 PLR, mean (SD)

135 (76.3)

118.5 (72.1)

0.260

 Fibrinogen (mg/dl), mean (SD)

395.3 (185.2)

392.5 (166.5)

0.950

 A1AT (mg/dl), mean (SD)

157.9 (42.6)

136.8 (29.1)

0.030

 IgE (kU/l), mean (SD)

176.5 (216.5)

177.8 (569.3)

0.990

 CRP (mg/l), mean (SD)

14.7 (20.6)

6.1 (8.8)

0.009

 Cholesterol (mg/dl), mean (SD)

180.1 (44.6)

201.8 (37.1)

0.010

 Bilirrubin (mg/dl), mean (SD)

0.73 (0.50)

0.6 (0.2)

0.060

OR

95%CI

p

A1AT (mg/dl)

1.02

1.00–1.03

0.03