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Table 1 Characteristics of the studied population and univariate comparisons between age- and FEV1-matched (3:1 ratio) men (n = 458) and women (n = 177)

From: Relationship between gender and survival in a real-life cohort of patients with COPD

Variables Women Men p
N 177 458  
Age (years) 62 [56–70] 63 [57–71] 0.4171
BMI 23.2 [20.2–27.1] 25.5 [22.1–29.0] < 0.0001
Malnutrition (BMI < 18 kg/m2) 25 (14.1%) 31 (6.8%) 0.003
Smoking (Pack-years) 38.0 [24.8–57.0] 41 [27–56] 0.4080
FEV1 (%) 54 [37–69] 53 [36–67] 0.4257
Number of moderate to severe exacerbations in the previous year 1 [0–3] 1 [0–2] 0.1209
mMRC 2 [1–3] 1 [1–2] 0.0014
mMRC ≥ 2 100 (56.5%) 212 (46.3%) 0.021
BOD index 3 [1–4] 2 [1–4] 0.0831
SGRQ 46 [32–57] a 43 [28–59] a 0.5776
Asthma history 28 (15.8%) 52 (11.4%) 0.128
Rhinitis 29 (16.4%) 42 (9.2%) 0.010
Chronic bronchitis 118 (66.7%) 302 (65.9%) 0.862
Hypertension 59 (33.3%) 159 (34.7%) 0.742
Left heart failure 16 (9%) 54 (11.8%) 0.321
Ischemic heart disease 11 (6.2%) 79 (17.2%) 0.0001
Diabetes mellitus 16 (9%) 58 (12.7%) 0.202
Obstructive sleep apnea 4 (2.3%) 40 (8.7%) 0.004
HAD total score 15 [11–21] b 12 [8–17] b < 0.0001
Anxiety HAD A ≥ 10 65 (44.5%)b 92 (27.6%)b 0.0001
Depression HAD D ≥ 10 34 (23.6%)b 59 (17.7%)b 0.136
3-year mortality 19 (10.8%) 51 (11.2%) 0.896
Age at death 72 [66–79] 68 [63–76] 0.1691
  1. BMI body mass index, HAD hospital anxiety and depression scale, mMRC modified medical respiratory council, SGRQ Saint George’s Respiratory Questionnaire. Data are provided as median [Q1 – Q3] or n (%), as appropriate
  2. aMissing data for SGRQ, n = 28 in women, n = 116 in men
  3. bMissing data for HAD scores: n = 33 in women, n = 131 in men