Fig. 6From: IL-22Ra1 is induced during influenza infection by direct and indirect TLR3 induction of STAT1Proposed mechanism of H1N1 induction of IL-22Ra1. H1N1 activates TLR3 via its dsRNA. TLR3 activation then increases levels of IFNβ. IFNβ then acts through its receptors, IFNαR1 and IFNαR2, and phosphorylates STAT1. pSTAT1 then dimerizes (likely with STAT2) and activates promoter upstream of IL-22Ra1Back to article page