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Table 4 Summary table of the pathways significantly upregulated in the Hallmark GSEA. The FDR 25% was the significance level cut off (FDR q < 0.25) only upregulated pathways were significant in both GSTCD SiRNA B and SiRNA C gene lists and there were no significantly different pathways with an FDR below 10%

From: Defining a role for lung function associated gene GSTCD in cell homeostasis

Upregulated Pathways Number of genes in pathway Number of Significant genes for B and C (%) B FDR q-val C FDR q-val
Adipogenesis 196 46 (23) 0.013 0.012
Bile Acid Metabolism 112 15 (13) 0.1 0.061
Estrogen Response early 199 34 (17) 0.16 0.00081
Fatty Acid Metabolism 158 24 (15) 0.16 0.045
Oxidative Phosporylation 199 62 (31) 0.037 0
P53 Pathway 199 46 (23) 0.1 0.0007
Peroxisome 103 29 (28) 0.2 0.038
Reactive Oxygen Species Pathway 47 12 (25) 0.1 0.061