Fig. 1

Typical small airway transcriptome features of the cell line donor’s small airway epithelium (SAE). Data shown is the unsupervised cluster analysis of microarray data from the cell line donor’s small airway epithelium with data from previously published-microarray datasets that include 9 matched-trachea, large airway and small airway epithelium samples. Genes differentially expressed between the paired trachea and SAE (fold changes > 2 fold, Benjamini-Hochberg corrected p < 0.05) were selected to generate the plot. Examples of SAE-enriched genes (GATA6, SOX9, LTF and SFTPB) are indicated. The donor’s SAE clusters with the reference SAE transcriptome, distinct from the large airway and trachea epithelium