Table 2 Unadjusted and adjusted (for baseline FVC and DLco) univariate analysis of overall survival in relation to baseline measures of collagen synthesis neoepitopes. Data shown for collagen-type 1 (P1NP), −type 3 (PRO-C3) and -type 6 (PRO-C6), the ratio of collagen synthesis: degradation ratios for collagen-type 1 (P1NP:C1M), −type 3 (PRO-C3: C3M), and –type 6 (PRO-C6: C6M) and lung function measurements (% predicted FVC and % predicted DLCO) in IPF subjects. The Hazard Ratio is based on a two-fold increase in the variable. Data are expressed as mean hazard ratio (HR) with 95% CIs for all thresholds and represent the associated change in mortality risk based on a 2-fold increase in the explanatory value

From: Biomarkers of collagen synthesis predict progression in the PROFILE idiopathic pulmonary fibrosis cohort