Table 3 Significant variants in COL6A3 associated with lung risk in males and females
From: COL6A3 polymorphisms were associated with lung cancer risk in a Chinese population
SNP | Model | Genotype | Control (%) | Case (%) | Adjustment With Age in males | Adjustment With Age in females | |||
|---|---|---|---|---|---|---|---|---|---|
OR (95%CI) | p#-value | OR (95%CI) | p#-value | ||||||
COL6A3 | rs115510139 | Allele | A/T | – | – | 1.38 (1.11–1.70) | 0.003 * | 0.92 (0.66–1.26) | 0.592 |
Codominant | A/A | 95 (27.5) | 71 (20.0) | 1.00 | 1.00 | ||||
A/T | 163 (47.3) | 165 (46.5) | 1.35 (0.93–1.97) | 0.118 | 0.83 (0.49–1.43) | 0.506 | |||
T/T | 87 (25.2) | 119 (33.5) | 1.86 (1.23–2.83) | 0.003 | 0.86 (0.46–1.59) | 0.624 | |||
Dominant | A/A | 95 (27.5) | 71 (20.0) | 1.00 | 0.018 | 1.00 | 0.497 | ||
A/T-T/T | 250 (35.1) | 284 (80.0) | 1.53 (1.07–2.18) | 0.84 (0.51–1.39) | |||||
Recessive | A/A-A/T | 258 (95.3) | 236 (66.5) | 1.00 | 0.012 | 1.00 | 0.870 | ||
T/T | 87 (25.2) | 119 (33.5) | 1.53 (1.10–2.12) | 0.96 (0.56–1.62) | |||||
Log-additive | – | – | – | 1.37 (1.11–1.68) | 0.003 | 0.92 (0.68–1.26) | 0.604 | ||
rs3736341 | Allele | T/C | – | – | 0.77 (0.60–0.99) | 0.038 * | 1.15 (0.80–1.66) | 0.437 | |
Codominant | T/T | 177 (53.5) | 214 (61.7) | 1.00 | 1.00 | ||||
T/C | 126 (38.1) | 109 (31.4) | 0.69 (0.49–0.95) | 0.025 | 1.30 (0.79–2.13) | 0.306 | |||
C/C | 28 (8.4) | 24 (6.9) | 0.71 (0.40–1.27) | 0.250 | 1.13 (0.51–2.50) | 0.766 | |||
Dominant | T/T | 177 (53.5) | 214 (61.7) | 1.00 | 0.019 | 1.00 | 0.331 | ||
T/C-C/C | 154 (46.5) | 133 (38.3) | 0.69 (0.51–0.94) | 1.26 (0.79–2.00) | |||||
Recessive | T/T-T/C | 303 (91.6) | 323 (93.1) | 1.00 | 0.486 | 1.00 | 0.970 | ||
C/C | 28 (8.4) | 24 (6.9) | 0.82 (0.46–1.44) | 1.02 (0.47–2.19) | |||||
Log-additive | – | – | – | 0.77 (0.61–0.98) | 0.034 | 1.14 (0.81–1.61) | 0.457 | ||
rs12052971 | Allele | G/A | – | – | 0.93 (0.73–1.18) | 0.555* | 1.24 (0.83–1.86) | 0.293 | |
Codominant | G/G | 193 (56.6) | 218 (61.6) | 1.00 | 1.00 | ||||
G/A | 119 (34.9) | 98 (27.7) | 0.72 (0.51–0.99) | 0.048 | 1.13 (0.67–1.89) | 0.657 | |||
A/A | 29 (8.5) | 38 (10.7) | 1.19 (0.71–2.01) | 0.513 | 1.74 (0.63–4.82) | 0.284 | |||
Dominant | G/G | 193 (56.6) | 218 (61.6) | 1.00 | 0.168 | 1.00 | 0.450 | ||
G/A-A/A | 148 (43.4) | 136 (38.4) | 0.81 (0.60–1.09) | 1.21 (0.74–1.98) | |||||
Recessive | G/G-G/A | 312 (91.5) | 316 (89.3) | 1.00 | 0.267 | 1.00 | 0.314 | ||
A/A | 29 (8.5) | 38 (10.7) | 1.34 (0.80–2.23) | 1.67 (0.61–4.54) | |||||
Log-additive | – | – | – | 0.94 (0.75–1.18) | 0.598 | 1.22 (0.83–1.81) | 0.313 | ||