Table 2 Significant COL6A3 variants associated with lung cancer susceptibility
From: COL6A3 polymorphisms were associated with lung cancer risk in a Chinese population
Gene | SNP | Model | Genotype | Control | Case | Unadjusted | Adjusted for Gender and Age | ||
|---|---|---|---|---|---|---|---|---|---|
OR (95%CI) | pa-value | OR (95%CI) | pb-value | ||||||
COL6A3 | rs115510139 | Codominant | A/A | 131 (26.7%) | 108 (21.2%) | 1.00 | 1.00 | ||
A/T | 232 (47.3%) | 235 (46.1%) | 1.23 (0.90–1.68) | 0.197 | 1.23 (0.90–1.68) | 0.196 | |||
T/T | 127 (26.0%) | 167 (32.7%) | 1.60 (1.13–2.25) | 0.008 | 1.61 (1.14–2.27) | 0.007 | |||
Dominant | A/A | 131 (26.7%) | 108 (21.2%) | 1.00 | 0.040 | 1.00 | 0.037 | ||
T/A-T/T | 359 (73.3%) | 402 (78.8%) | 1.36 (1.01–1.82) | 1.36 (1.02–1.83) | |||||
Recessive | A/A-A/T | 363 (74.0%) | 343 (67.3%) | 1.00 | 0.018 | 1.00 | 0.015 | ||
T/T | 127 (26.0%) | 167 (32.7%) | 1.39 (1.06–1.83) | 1.41 (1.07–1.85) | |||||
Log-additive | – | – | – | 1.27 (1.07–1.50) | 0.007 | 1.27 (1.07–1.51) | 0.006 | ||