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Table 1 Characteristics of the study populations

From: Pulmonary gas exchange in hereditary hemorrhagic telangiectasia patients with liver arteriovenous malformations

 

Controls

HHT

PAVMs

P + LAVMs

LAVMs

n

15

7

8

25

21

Age, yr. a

46 (23;53)

27 (18;59)

40 (35;51.75)

36 (29;47)

43.7 (32.5;55.5)

Female/Male ratio a

10/5

2/5

4/4

16/9

17/4

LVEF,% a

nd

69 (61;73)

63 (61.5;71.75)

70 (67;76)

71 (68.5;75.5)

(A-a) O2 a (kPa)

nd

1.25 (0;2.92)

2 (1.5;2.85)

2 (0.5;3.7)

1.15 (0.5;1.75)

Hb, g/dL a

nd

14.9 (14.5;15.1)

14.55 (13.8;15.2)

14.2 (13.5;15)

14 (12.1;14.7)

TLC, % a

93.8 (90;100)

99 (90;102)

104.5 (99.25;113)

104 (94.5;111.5)

101 (91;117.5)

DLCO,% a

88.5 (85;92.8)

85 (80;97)

104 (91.75;110)

81 (74.5;86.5)

91 (79.5;98.5)

DLCO/VA,% a

95.2 (90.6;112.9)

98 (92.5;102.5)

100 (78;111)

88 (81;95)

94 (86.25;104)

DLNO/DLCO

4.1 (3.8;4.3)

4.5 (4.3;4.7)#

4.3 (4.2;4.6)

4.5 (4.25;4.6)#

4.3 (3.95;4.5)

Vc, % a

85 (76.7;91.9)

85 (79;93)

103.5 (94.25;110.8)

78 (73;89)

94 (79;97)

Dm, % a

125.5 (120.7;139.2)

113 (102;119)

135.5 (129.3;147.3)

107 (98.5;116)

117 (100;125.5)

Vc/Dm ratio

1.09 (1.01;1.2)

1.15 (1.13;1.25)

1.21 (1.12;1.26)

1.16 (1.11;1.42)

1.35 (1.18;1.62)b

  1. Values given as median (25%;75% quartiles), a no difference between groups; b: p < 0.05 vs other groups; # p = 0.01 vs controls; HHT Hereditary Hemorrhagic Telangiectasia patients without arteriovenous malformations, PAVMs pulmonary arteriovenous malformations, P + LAVMs Pulmonary+Liver arteriovenous malformations, LAVMs Liver arteriovenous malformations. LVEF left ventricular ejection fraction, (A-a) O2 alveolar-arterial O2 difference at rest, Hb hemoglobin level g/dL, TLC, % total lung capacity, % predicted, DLCO diffusing capacity of the lung for carbon monoxide, DLCO/VA transfer coefficient for carbon monoxide, Vc pulmonary capillary blood volume, Dm alveolar-capillary membrane conductance, DLNO/DLCO diffusing capacity of the lung for nitric oxide/DLCO ratio