Fig. 2

Protective effect of TAF on the BLM-injury mouse model. a Time course of BLM and TAF administration, as well as experimental termination. Mice were instilled intratracheally with BLM (2 mg/kg in 50 μl of saline). The treatment group received TAF (5.125 mg/kg in 50 μl of saline) intragastrically for 3 weeks separately on day 0, day 7, or day 14 after BLM instillation. The mice were sacrificed on day 21, day 28, or day 35 following BLM delivery, and lung tissues were collected for further study. b Body weight loss was lower in TAF group (BLM + TAF) than in BLM group (BLM + saline) within two weeks, and ponderal growth was higher in TAF group, compared to BLM group from the third week. c Survival rate across different treatment group. Mice in control group were all survival, and survival rate was higher in TAF group than in BLM group. The results were shown as mean ± standard error of mean (SEM), and statistical significance across intervention groups was determined using one-way ANOVA. #P < 0.05 vs. control group (saline + saline). *P < 0.05 vs. BLM group (BLM + saline)