Fig. 2
From: Azithromycin induces epidermal differentiation and multivesicular bodies in airway epithelia
Heatmaps showing upregulated genes involved in late epidermal differentiation and barrier formation as a result of Azm treatment of airway epithelia. Analysis of RNA sequencing of VA10 cells after 4, 10 and 22 days of treatment of Azm in ALI culture. Sequencing was done on triplicate samples. Heatmap showing hierarchically clustered log2(ratio) data, where the ratio is defined as mRNA expression level in control cells to Azm-treated cells. Data are shown for genes differentially expressed at one or more of the three time points during differentiation. Heatmaps showing up/downregulation of transcripts arranged in gene ontology (GO)-groups involved, including (a) cornification, (b) regulation of water loss via skin, (c) desmosomal organization, (d) epidermal differentiation complex (EDC), (e) corneocyte lipid envelope (CLE). Green color represents increased gene expression relative to red color representing decreased expression