Table 3 Relationships between risk of death from any cause with consensus and weight-loss definitions of cachexia in COPD cases from ECLIPSE
From: It’s more than low BMI: prevalence of cachexia and associated mortality in COPD
Model | Covariate | HR (95% CI) | P-value | |
|---|---|---|---|---|
Model 1 | Consensus | 3.2 (1.6–6.6) | 0.001 | |
Pack-years | 1.0 (0.99–1.01) | 0.1 | ||
BMI category (ref = Normal) | Low | 0.67 (0.23–2.0) | 0.46 | |
Overweight | 0.30 (0.14–0.65) | 0.002 | ||
Obese | 1.5 (0.86–2.5) | 0.16 | ||
Sex (ref = males) | 0.86 (0.49–1.5) | 0.49 | ||
Age | 1.1 (1.0–1.1) | < 0.001 | ||
FEV1% pred | 0.98 (0.96–0.99) | < 0.001 | ||
Model 2 | Weight-loss | 3.2 (1.8–5.6) | < 0.001 | |
Pack-years | 1.0 (0.998–1.01) | 0.17 | ||
BMI category (ref = Normal) | Low | 0.68 (0.24–2.0) | 0.48 | |
Overweight | 0.30 (0.14–0.66) | 0.003 | ||
Obese | 1.5 (0.89–2.7) | 0.12 | ||
Sex (ref = males) | 0.78 (0.45–1.4) | 0.39 | ||
Age | 1.1 (1.0–1.1) | < 0.001 | ||
FEV1% pred | 0.97 (0.96–0.99) | 0.003 | ||
Model 3 | Consensus or weight-loss | 2.9 (1.7–5.1) | < 0.001 | |
Pack-years | 1.0 (0.998–1.01) | 0.16 | ||
BMI category (ref = Normal) | Low | 0.62 (0.21–1.8) | 0.39 | |
Overweight | 0.31 (0.14–0.68) | 0.003 | ||
Obese | 1.6 (0.91–2.7) | 0.11 | ||
Sex (ref = males) | 0.80 (0.46–1.4) | 0.44 | ||
Age | 1.07 (1.03–1.1) | < 0.001 | ||
FEV1% pred | 0.97 (0.96–0.99) | 0.003 | ||